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Articles by B.H. Park
Total Records ( 2 ) for B.H. Park
  I. Lee , J. Yu , Y. Yoon , H.J. Gim , S.M. Lee , J.W. Park , R. Jeon and B.H. Park
  The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in adipocyte differentiation and is the target for anti-diabetic drugs known as thiazolidinediones. Here, we synthesized and characterized a new PPARγ agonist, SPA0432. COS-7 cells treated with SPA0432 showed significantly increased PPARγ transcriptional activity compared to that of vehicle-treated cells. However, its efficacy was less than that of rosiglitazone. Using a standard differentiation protocol, SPA0432 effectively enhanced differentiation of 3T3-L1 preadipocytes as evidenced by increased lipid droplet formation and triglyceride accumulation. Real-time RT-PCR analysis indicated that SPA0432 significantly increased the expressions of adipogenesis-related genes, CAAT/enhancer binding protein α, PPARγ, fatty acid synthase, aP2 and lipoprotein lipase and significantly decreased the expression of Pref-1, a preadipocyte marker. Moreover, SPA0432 increased insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. These results suggest that SAP0432 may exert beneficial effects against insulin resistance through its ability to promote adipocyte differentiation and insulin-stimulated glucose uptake.
  S.J. Shin , U.J. Bae , M. Ahn , S.O. Ka , S.J. Woo , S.O. Noh , Y.S. Kwon , K.H. Jung , J.H. Wee and B.H. Park
  Purple sweet potato is a widely consumed food around the world has been reported to possess antioxidant, antimutagenic and memory-enhancing effects. However, antiobesity effect of PSP is not clear. The objective of this study was to determine the effects of Purple Sweet Potato Extracts (PSPE) on serum and fecal lipid profiles, body weight gain, body fat percentage and hepatic lipogenesis. Mice were administered a standard chow diet, a 45% high-fat diet, or a high-fat diet with various doses of PSPE. Mice that were fed a high-fat diet containing PSPE were found to have lower increases in body and adipose tissue weights and lessened occurrences of hepatic steatosis than mice that were fed a high-fat diet without PSPE. The decreased adiposity induced by PSPE accounted for lower serum levels of leptin and a higher adiponectin/leptin ratio. PSPE administration also resulted in a significant decrease in serum and hepatic triglyceride and cholesterol levels and a significant increase in fecal triglyceride and cholesterol levels when compared to the high-fat group. To identify the mechanism by which PSPE induced its antiobesity effect, the expression of lipogenesis-related genes that were induced in high fat-fed mice was investigated. PSPE suppressed the expression of Sterol Regulatory Element-Binding Protein (SREBP)-1, Acyl-CoA Synthase (ACS), Glycerol-3-Phosphate Acyltransferase (GPAT), HMG-CoA Reductase (HMGR) and Fatty Acid Synthase (FAS) in liver tissue in mice provided the high-fat diet. These findings suggest that the antiobesity effect of PSPE in high fat-fed mice occurs through its modulation of lipogenesis in the liver and inhibition of dietary lipid absorption.
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