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Articles by B.A. Adeniyi
Total Records ( 4 ) for B.A. Adeniyi
  B.A. Adeniyi , F.S. Oluwole and F.M. Anyiam
  Methanol extract of Allium sativum was investigated for in vitro antibacterial activity against H. pylori using standard strain ATCC 43504 and three clinical isolates (UCH97009, UCH99041 and UCH99052) and also for anti ulcer effect in rat. All the strains except UCH99041 were inhibited by thefinal concentration of the tested extract (6 mg mL-1) to varying degrees. The Minimum Inhibitory Concentration (MIC) against all susceptible strains ranged between 153 and 625 μg mL-1. Urease activity of both UCH97009 and UCH99052 strains decreased with increase in the concentration of the extract while the cell surface hydrophobicity of two of the strains was reduced by the extract as there was no aggregation of the cell by the extract. SAT titre was >3.0 M. Methanol extract of A. sativum reduced mean ulcer score from 13.63±1.33 in control to 10.06±1.27 in extract treated. The anti- ulcer effect was however not significant (p>0.05). The acute toxicity test (intraperitonial administration) methanol extract in mice gave LD50 of 8.7 g kg-1 body weight. The result indicates that Allium sativum taken at a low dose may have some therapeutics potentials against gastric ulcers associated with H. pylori infection.
  B.A. Adeniyi , C.C. Amajoyi and S.I. Smith
  Fifty-two multidrug resistant local uropathogenic Escherichia coli, Klebsiella spp., Proteus spp. and Pseudomonas spp. isolates were tested for susceptibility to 10 antimicrobial agents. Tetracycline (100.0%) and ampicillin (94.2%) showed the highest rates of resistance and ciprofloxacin (50.0%) demonstrated the lowest. The majority of the multiple drug resistant (MDR) isolates showing concurrent resistance to all 10 agents (n = 17) was a component of 32.7%. A total of 23 antimicrobial resistance patterns was observed. The predominant phenotype (32.7%) amongst the isolates included resistance to ciprofloxacin, cefuroxime, ceftriaxone, ampicillin, gentamicin, nalidixic acid, nitrofurantoin, co-trimoxazole, streptomycin and tetracycline. A 38.5% (n = 10) of the isolates were carrying plasmids of sizes estimated above 2.1 kb. After curing, most of the mutant strains lost their plasmids as was corroborated by their improved susceptibilities. Given that uropathogens are demonstrating increasing antimicrobial resistance, epidemiological investigation using the molecular characterization tools is highly necessary.
  A.A. Odetola , F.S. Oluwole , B.A. Adeniyi , A.M. Olatiregun , O.R. Ikupolowo , O. Labode , K.O. Busari and J.A. Shorinola
  Leaf extracts of Parquetina nigrescens (AAfz.) Bullock, a plant commonly employed for the treatment of gastro-intestinal disorders in Nigeria was tested for antimicrobial activity and gastro-intestinal protective effect. Aqueous leaf extract showed antimicrobial activity against a range of bacteria in the following order of activity: Staphylococcus aureus > Salmonella typhi > Proteus mirabilis > Pseudomonas aeruginosa > Bacillus subtilis > Proteus vulgaris, whereas the ethanol extract was effective only against Pseudomonas aeruginosa and Salmonella typhi. The aqueous extract also significantly reduced gastric acid secretion, reduced ethanol-induced gastric ulceration (p<0.05) and caused elevation in gastric mucus secretion. The antimicrobial activity against the common pathogenic microbes S. aureus, S. typhi and P. aeruginosa may account for its acclaimed potency against diarrhea. In addition, its protective effect against oral administration of absolute ethanol reflected by the increased mucus secretion and decreased gastric acid secretion may also be responsible for its claim as having anti-ulcer property.
  B.A. Adeniyi , T.O. Lawal and S.B. Olaleye
  The crude extracts of Eucalyptus camaldulensis were investigated for their in vitro antimicrobial and gastro-protective activities in albino rats. The antimicrobial activity was investigated by screening the crude plant extract for activity against Candida albicans and clinically isolated gentamycin resistant wound bacteria viz: Staphylococcus aureus UCH 2600, Escherichia coli UCH 2554, Pseudomonas aeruginosa UCH 2780 and Proteus mirabilis UCH 2773. These microorganisms were susceptible to the crude extracts at a 10 mg mL-1 concentration. The gastroprotective activity of the methanol extract of Eucalyptus camaldulensis (MEEC) was investigated in rats. Gastro protection was evaluated against gastric mucosal damage induced by ethanol/HCl mixture. The Hcl/Ethanol mixture (1.5 mL of 0.15 N HCl in 70% ethanol) caused severe gastric damage with ulcer index 2.7±0.33. Pre-treatment of animals with crude extract of Eucalyptus camaldulensis leaf 200 and 1000 mg kg-1 orally for 1 h significantly reduced the formation of ulcer by the HCl/ethanol mixture with preventive ratios of 56 and 89%, respectively. Ranitidine afforded 92.5% protection. The results suggest that crude extracts of Eucalyptus camaldulensis has both antimicrobial and anti-ulcer properties.
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