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Articles by B. Zhang
Total Records ( 4 ) for B. Zhang
  Y.T. Xing , S.P. Wang , J.X. Fan , T. Yang , L.L. Li , B. Zhang and D.F. Xiao
  This study was conducted to determine the effects on performance and immune responses of Linwu ducks supplemented with high lysine-yielding Bacillus subtilis. The 200 and 41 days old female commercial Linwu ducklings were distributed randomly into four groups of 60 ducks each which were further replicated to three groups of 20 each. The ducks were placed on one of four dietary treatments: basal, basal with antibiotic (150 mg Aureomycin whose effective content was 15% per kg feed) and fed with basal diet but deleted lysine (0.15%) and respectively added 5x108 CFU and 5x1010 CFU Bacillus subtilis per kilogram feed. The trial lasted for 63 days. Average body weight gain for 63 days breeding was observed significantly increase in antibiotic-added group (p<0.05) but not showed in supplemented Bacillus subtilis groups. It was basically lying in the same level to average feed intake and feed conversion ratio as accessed from each group. Mortality experienced pronounced recession with Bacillus subtilis or Aureomycin addition. Breast meat, leg meat and liver relative weigh were greatly improved by fed with 5x1010 CFU kg-1 Bacillus subtilis supplemented diet, although, dressing percentage, semi-eviscerated percentage, eviscerated percentage and percentage of abdominal fat were unaffected. No marked significance was observed in serum profile, except for serum Total Protein (TP) increasing as the consequence of 5x1010 CFU kg-1 Bacillus subtilis supplement. Supplement 5x1010 CFU kg-1 Bacillus subtilis also increased crude protein proportion in meat. Amino acid percentages in meat varied differently between experimental treatments. Additionally, the results in the current research revealed that diet supplemented with Bacillus subtilis tended to markedly suppress IL-2 both in spleen and thymus compared with control. Dietary treatment with 5x1010 CFU kg-1 Bacillus subtilis addition or Aureomycin addition down regulated IL-18 in spleen when compared with control. Treatments did not induce any significant effects on INF-α, INF-γ, IL-1 and IL-10 gene expression both in thymus and spleen. It was concluded that dietary supplementation with these high lysine-yielding Bacillus subtilis showed promising effects as alternatives for antibiotics due to it had a favor to growth performance and slaughter performance and depression on inflammatory cytokines overproduction which was stimulated by pathogens.
  B. Zhang , W.H. Lin , Y.J. Wang and R.L. Xu
  In order to evaluate the role of vertical polypropylene belts in wastewater treatment, changes in both water quality parameters and ciliate community characteristics were analyzed for 10 days. This experiment was carried out in four outdoor concrete tanks that were randomly assigned to two groups: the experimental group (with vertical polypropylene belts) and the control group (without vertical polypropylene belts). In the experimental group, the dissolved oxygen concentration increased quickly, the concentration of nitrogen compounds decreased sharply and polysaprobic ciliates were replaced by oligosaprobic ciliates. In the control group, however, the wastewater quality improved very little and polysaprobic ciliates remained as the predominant species throughout the course of the experiment. Analysis of ciliate community succession in wastewater showed that vertical polypropylene belts played a key role in water treatment by providing a temporary refuge for ciliates and serving as a colonization center, allowing for ciliate adaptation to their new surrounding niche. Additionally, this study suggests that the ciliate community on vertical polypropylene belts may possess a unique adjustment mechanism that allows it to cope with changes in the surrounding environment.
  J.L. Yang , H.J. Hao , B. Zhang , Y.X. Liu , S. Chen and Y.Q. Na
  Measurement of soluble CD30 (sCD30) levels may predict acute rejection episodes (ARE). To explore the value of sCD30 after transplantation, we tested serum sCD30 levels in 58 kidney transplant cases at 1 day before and 7 and 28 days after transplantation by enzyme-linked immunosorbent assay (ELISA). The incidences of ARE after kidney transplantation were recorded simultaneously. Meanwhile, 31 healthy individuals were selected as a control group. The results showed a relationship between sCD30 level in serum before kidney transplantation and the incidence of ARE. However, the relationship was more significant between serum sCD30 levels at day 7 after kidney transplantation and the incidence of ARE. There was no obvious relationship between serum sCD30 levels at day 28 after kidney transplantation and the incidence of ARE. These results suggested that the level of sCD30 at day 7 posttransplantation provides valuable data to predict ARE.
  X. Yua , B. Zhang , C. Xing , B. Sun , M. Liu , W. Zhang and M. Gu
 

Objective: To investigate the differential effects of cyclosporine (CsA) and tacrolimus (TAC) on renal expression of P-glycoprotein (P-gp) in a cohort of kidney transplant recipients.

Methods: We enrolled 78 cadaveric kidney transplant recipients recuring basal immunosuppressive protocol with prednisone + mycophenolate mofetil + calcineurin inhibitor (CsA or TAC).

Results: We performed a 3-year analysis of 60 patients. There was no difference in age, gender, or cold ischemic time between two groups, Serum creatinine, urine protein, and blood fat levels of the CsA group were significantly higher than the TAC group (P < .05), while the creatinine clearance was remarkably lower than the TAC group (P < .05). The incidence of tubular atrophy, arteriohyalinosis, and interstitial fibrosis and nephrotoxic lesions among the CsA group were higher than the TAC group, as well as the chronic allograft nephropathy (CAN) Banff score (P < .05).® P-gp was predominantly present in the a tubular apical membrane, basal membrane, and cytoplasm. The intensity and extent of tubular staining score in the CsA group were lower compared with the TAC group (P < .01 and P < .05, respectively).

Conclusion: Less P-gp expression in the CsA group than the TAC group may be the molecular action pathway of the high incidence of CsA nephrotoxicity and CsA-induced CAN. This study perhaps unraveled a novel interpretation that the differences of CsA and TAC on long-term allograft survival were due to increases dynamic effects of CsA at the exposures employed in this study.
 
 
 
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