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Articles by B. Wang
Total Records ( 4 ) for B. Wang
  C. Zhu , J. Yu , Z. Yang , K. Davis , H. Rios , B. Wang , G. Glenn and E. C. Boedeker
  Enterohemorrhagic Escherichia coli (EHEC) strains are important human food-borne pathogens. EHEC strains elaborate potent Shiga toxins (Stx1, and/or Stx2) implicated in the development of hemorrhagic colitis (HC) or hemolytic-uremic syndrome (HUS). In this report, we evaluated the immunogenicity and protective efficacy of Stx1 subunit B (StxB1) administered by transcutaneous immunization (TCI). Three groups of Dutch Belted rabbits received patches containing StxB1, StxB1 in combination with Escherichia coli heat-labile enterotoxin (LT), or LT alone. An additional group of naïve rabbits served as controls. The protective efficacy following TCI with StxB1 was assessed by challenging rabbits with a virulent Stx1-producing strain, RDEC-H19A, capable of inducing HC and HUS in rabbits. Antibodies specific to StxB1 from serum and bile samples were determined by enzyme-linked immunosorbent assay and toxin neutralization test. Rabbits immunized with StxB1 demonstrated improved weight gain and reduced Stx-induced histopathology. Rabbits receiving StxB or StxB1/LT showed a significant increase in serum immunoglobulin G titers specific to StxB1 as well as toxin neutralization titers. These data demonstrated that the StxB delivered by TCI could induce significant systemic immune responses. Thus, Stx subunit B vaccine delivered by a patch for a high-risk population may be a practical approach to prevent (and/or reduce) Stx-induced pathology.
  Z. Liu , B. Wang and Q. Tang
  In WSNs (Wireless Sensor Networks), an optimized way of prolonging the networks lifetime and flooding packets is to find the minimum CDS (Connected Dominating Set). In this study, a new method called ATISA (Approximation Two Independent Sets based Algorithm) for constructing CDS is proposed. The ATISA has three stages. The first stage is constructing a connected set CS (connected set) and the second stage is constructing a connected dominating set CDS and the third stage is pruning the redundant dominators of CDS. The performance ratio of ATISA is approximately (9.67+19nk) when the number of nodes is bigger enough and the message complexity is O(n). Compared with some famous CDS construction algorithms, ATISA constructs the CDS with the smallest size.
  Y Tu , J Lu , J Fu , Y Cao , G Fu , R Kang , X Tian and B. Wang

Neuroepithelial-transforming protein 1 is a member of the guanine nucleotide exchange factor family, a group of proteins which are known to activate and thereby regulate Rho family members. Deregulation of neuroepithelial-transforming protein 1 expression has been found in certain types of human tumors. To investigate its prognostic value in human gliomas, which is currently unknown, we examined the correlation between neuroepithelial-transforming protein 1 expression and prognosis in patients with gliomas.


Immunohistochemical staining was performed to detect neuroepithelial-transforming protein 1 expression patterns in the biopsies from 96 patients with primary gliomas. Kaplan–Meier survival and Cox's regression analyses were performed to evaluate the prognosis of patients.


Immunohistochemical analysis with anti-neuroepithelial-transforming protein 1 antibody revealed that neuroepithelial-transforming protein 1 was significantly associated with the Karnofsky performance scale score and World Health Organization grades of patients with gliomas. Especially, the positive expression rates of neuroepithelial-transforming protein 1 were significantly higher in patients with higher grade (P = 0.001) and lower Karnofsky's performance scale score (P = 0.005). The median survival of patients with high neuroepithelial-transforming protein 1 expression was significantly shorter than that with low expression and without expression (316, 892 and 1180 days, respectively). Cox's multifactor analysis showed that the Karnofsky performance scale (P = 0.01), World Health Organization grade (P = 0.008) and neuroepithelial-transforming protein 1 (P = 0.006) were independent prognosis factors for human glioma.


Taken together, our study indicates for the first time that neuroepithelial-transforming protein 1 status may be a highly sensitive marker for glioma prognosis and suggest that the expression patterns of neuroepithelial-transforming protein 1 might be a potent tool for predicting the clinical prognosis of glioma patients.

  X. Zhang , X. Wang , B. Wang , T. Sugi and M. Nakamura
  The onset detection of muscle activation is an essential issue in electromyogram (EMG) control. In this paper, a novel approach based on EMG power with automatic adaptive threshold is proposed to address this issue. The purpose is to develop an effective EMG-controlled meal assistance robot. Taking into account the individual difference such as contraction power and resting power, the threshold of onset detection is set with respect to the latest EMG signal. The results show the method is able to adjust automatically to avoid false alarms, and works well when the contraction power varies. Implementation of this EMG-controlled meal assistance robot may provide limb-deficient patients with an effective and comfortable human-machine assistance interface.
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