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Articles by B. Mbatchi
Total Records ( 2 ) for B. Mbatchi
  J.T. Banzouzi , M.C. Makambila Koubemba , A. Prost , B. Mbatchi and A.A. Abena
  A series of semi-structured interviews with traditional practitioners from the South of Congo Brazzaville allowed us to gather the names of 200 plants entering traditional preparations against pain. Some were already well studied for their analgesic and/or psychotropic properties but others were very little documented. We selected 51 plants, belonging to 32 families, which seemed promising but had not yet been studied in laboratory. For each plant, we collected the following data: used plant parts, modes of preparation and administration, as well as indications relating to the treatment when they were available. Around 150 traditional recipes were thus recorded. In analgesic as well as in psychotropic preparations, leaves are the most used part (43 and 40% of citations, respectively), followed by roots or root bark (17-13%), aerial part (11-6%), stem and trunk bark (20-11%). Decoction is the major mode of preparation and in most cases the preparation is drunk or applied locally (friction, massage). As a rule, plants used, dosage and length of the treatment shall vary depending to age, sex and general health condition of the patient. Self-medication can thus be very dangerous, all the more because some of the plants we studied are easily bought in the market places of Brazzaville or Pointe Noire.
  A. Tibiri , J.T. Banzouzi , A. Traore , G.O Nacoulma , I.P. Guissou and B. Mbatchi
  This study was aimed to assess the possible toxic effects of Entada africana, a widely used African medicinal plant. The acute toxicity of the methanolic stem bark and leaf extracts of Entada africana Guill. and Perr., (Mimosaceae) was assessed on mice. It revealed an average toxicity with a LD50 of 146.7 and 249.9 mg kg-1 body weight for stem barks and leaves, respectively. The extracts showed no cytotoxicity against KB and Vero cells. Sub-chronic toxicity was assessed in rabbits, which received orally, daily for a month, a dose corresponding to 10% of the LD50. Compared to the control group this dose caused no significant (p>0.05) modification of haematological and biochemical parameters, total cholesterol, urea, creatinine and aspartate amino-transferase (AST). The extracts lowered serum glucose significantly (p<0.05) by 52% at first two weeks of treatment. The stem bark and leaf extracts showed temporary decrease (p<0.05) of Alanine amino transferase (ALT) by 26.1 and 39.1%, respectively. The stem bark extracts increased triglycerides significantly (p<0.01) by 108% at the end of last week of treatment. These investigations seemed to indicate the safety ob sub-chronic oral administration (up to 14.67 and 24.9 mg kg-1 body weight) of the methanolic extracts of Entada africana in rabbits.
 
 
 
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