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Articles by B. Larijani
Total Records ( 5 ) for B. Larijani
  B. Larijani , M. Salimi , N. Pourkhalili , A. Mohammadirad , M. Baeeri , A. Nili-Ahmadabadi and Mohammad Abdollahi
  IMOD as a multi-herbal-selenium electromagnetically-treated combination was tested for its potential on the function and level of Reactive Oxygen Species (ROS) in isolated rat pancreatic islets. After Laparotomy, pancreas were removed and islets were isolated and incubated in RPMI 1640 for 24 h and then islets were separated and divided into several tubes containing ten in each. IMOD at logarithmic doses (0.1, 1, 10, 100 and 1000 ppm) were added to islets and incubated for 24 h and then static insulin secretion, at low dose (2.8 mM) glucose and high dose (16.7 mM) glucose was tested. Cells viability and ROS were also determined. IMOD at 0.1 ppm increased islet insulin secretion in response to glucose in both basic and stimulation levels. This drug at 1 ppm dose only increased insulin concentration in stimulation levels of glucose. IMOD at 10, 100 and 1000 ppm decreased insulin secretion in both levels of glucose. The viability at the doses of 0.1 and 1 ppm increased. The result of ROS test showed a decrease although significant, at the lower dose (0.1 μM) but increased dose-dependently at the doses of 10, 100 and 1000 ppm. IMOD has significant anti oxidative effects at low doses and improves viability and insulin secretion of isolated islets in both basic and stimulation levels of glucose. Pretreatment with IMOD may improve transplant outcome and graft function. Its effect in insulin release maybe promising in treatment of diabetes.
  K. Moradzadeh , B. Larijani , A.A. Keshtkar , A. Hossein-Nezhad , R. Rajabian , I. Nabipour , G.H. Omrani , A. Bahrami , M.M. Gooya and A. Delavari
  There is no agreement about normal level of vitamin D and its deficiency stages. For finding normative value of Vitamin D and evaluating the state of vitamin D level in Iranian population we revised the data that was collected in Iranian national Multi-center Osteoporosis Study (IMOS). We chose 5 cities with different climates; individuals were selected by random cluster sampling. Healthy people aged 20-69 were entered into the study and serum vitamin D and PTH levels were measured. We stratified subjects based on their vitamin D levels in 7 groups and compared mean PTH levels of adjacent groups. We evaluated 5329 blood samples for vitamin D and PTH and found three steps of PTH elevation with decreasing vitamin D levels for women (40, 25 and 12 nmol L-1) and two (35 and 25 nmol L-1) for men. We use these values as cutoff levels for definition of normal, mild, moderate and severe vitamin D deficiency states. Based on these cutoffs, prevalence of all stages of vitamin D deficiency was unexpectedly high in all cities. Vitamin D deficiency state was seen in 75.1% of women and 72.1% of men. The high prevalence of vitamin D deficiency in Iran is similar to the results of other studies in Middle East area and indicates a need for a careful search for a determination of cause and need for regular fortification program.
  S. Hasani- Ranjbar , H. Vahidi , S. Taslimi , N. Karimi , B. Larijani and M. Abdollahi
  Several drugs may increase blood prolactin concentration. Dopamine receptor antagonists are one of the most common causes of hyperprolactinemia. To reduce happening of hyperprolactinemia, some medicinal plants have been traditionally used. This review focuses on the efficacy of effective herbal medicines in the management of human drug-induced hyperprolactinemia. PubMed, Scopus, Web of science, Cochrane library database were searched for any relevant studies that investigated the effect of herbal medicines on drug induced hyperprolactinemia up to May 2010. The inclusion criteria were clinical trials studied efficacy of herbal medicines in drug-induced hyperprolactinemia. Among different compounds, four herbal supplements including Shakuyaku-kanzo-to (TJ-68), Peony-Glycyrrhiza Decoction (PGD), Zhuangyang capsule, Tongdatang serial recipe (TDT) were found clinically effective and safe in management of drug-induced hyperprolactinemia. Although, the quality of included clinical trials was low not allowing us to conduct a meta-analysis but positive results on efficacy (TJ-68), (PGD), Zhuangyang capsule and (TDT) cannot be ignored. Interestingly compounds with prolactin-suppressive effects have a number of diterpenes mainly clerodadienols that seem almost identical for their efficacy. Further studies to isolate and characterize constituents of the effective herbs are needed to reach novel therapeutic and more effective agents.
  J. Mohammadi-Asl , B. Larijani , Z. Khorgami , S.M. Tavangar , V. Haghpanah and P. Mehdipour
  The aim of this study was to investigate the frequency of the BARFV600E mutation in Papillary Thyroid Carcinoma (PTC) in Iranian population through PCR-RFLP. Fifty formalin-fixed paraffin-embedded and 26 frozen thyroid tumors including 28 PTCs, two undifferentiated thyroid carcinoma and 46 benign thyroid tumors were evaluated. The BARFV600E mutation was detected in 20 of 28(71.4%) PTCs, but failed to distinguish the mutant allele in benign thyroid tumors. The age, sex, extrathyroid extension and lymph node metastases distribution did not, significantly, differ between the patients with and without the BARFV600E mutation. In conclusion, these findings might pave our way towards considering the BRAFV600E mutation in PTCs in the regions with high prevalence of this alteration as a molecular marker.
  M. Mokhtari-Dizaji , M. R. Dadras and B. Larijani
  DXA and QUS assessments in vivo have been shown to be predictive of osteoporosis and future fractures. In clinical measurements, bone thickness can affect bone mineral density and ultrasound parameters. Previous in vitro studies have demonstrated contradictory reports about relationship between bone mineral density and so ultrasound parameters with bone thickness, separately. In this study, DXA, phalangeal QUS and calcaneus QUS measurements were conducted on rabbit bone in vivo using clinical instruments. We have selected rabbit’s bones that have low BMD and more collagen tissue to predict structure not only measures BMD, but is also sensitive to the structure of the bone. To investigate the effect of bone thickness on the measured parameters, two regions of femur and tibia bones (N = 44) were processed: up (1/3 of length) and down (2/3 of length) for BMC, areal BMD, volumetric BMD, AD-SOS, UBPI, BTT, SOS, BUA and SI measurements and bone thickness-corrected SOS and bone thickness corrected BUA. The paired student's t-test analysis of densitometric and ultrasonic characteristics extracted by DXA, Phalangeal and calcaneus quantitative ultrasound showed significant differences (p<0.05) between densitometric and ultrasonic parameters of two groups of up and down of the femur and two groups of up and down of the tibia, with the exception of SOS and SI (p>0.05). It shows that BMC, BMDa, AD-SOS, UBPI, BTT and BUA correlate well with the bone thickness of the tibia and the femur. Among the femur parameters, the highest correlation (r = 0.755) was obtained for BMC parameter. But in the tibia, measurements at AD-SOS, UBPI and BUA inversely correlated with bone thickness, that could be arise from the tibia bone structure. This bone has collagen and non mineral structures more than bone mineral density. Correlation analyses of the bone thickness with the thickness-corrected DXA and ultrasound parameters revealed that corrected BMD (BMDv) is independent from thickness, but corrected parameters excluding SOSc and BUAc showed significant correlation coefficient than uncorrected. Linear regression analyses were used to examine the relationship between DXA and ultrasound parameters with bone thickness and the regression functions for each parameters (with correlated significant) is given. We concluded that BMDv, SOS and SI are independent from bone thickness (with range of 5-9 mm). Thus, the ability of these parameters to discriminate low density or osteoporotic bone from normal bone may be limited if differences in bone thickness are not accounted for. This result may be at least in part due to large precision error measurement of the bone thickness, in vivo study.
 
 
 
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