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Articles by B. Elmahdi
Total Records ( 5 ) for B. Elmahdi
  Afaf I. Abuelgasim , Rehab Omer and B. Elmahdi
  The present study aimed to clarify the toxic effect of potassium bromate in Wistar albino rats. Thirty rats were divided into 5 groups. The first group severed as control and the other four groups received potassium bromate orally at doses 50, 100, 200 and 400 mg kg-1 body weight (b.wt.) for 21 days. Rats received 400 mg kg-1 b.wt. died within 3 days and those received 200 mg kg-1 b.wt. died on the 18th day post treatment. The body weights of rats treated with potassium bromate were not affected but the relative weights of the kidney and liver were significantly increased (p<0.05) in the group of rats received 100 mg kg-1 b.wt. potassium bromate compared to the control group. Clinically difficulty in breathing and depression occurred in those rats received 100 and 200 mg kg-1 b.wt. of potassium bromate. A significant (p<0.05) increase of urea, creatinine and potassium beside a decrease in Na level was evident in the groups received 100 and 200 mg kg-1 b.wt. of potassium bromate. Histopathological examination of the groups of rats received 100, 200 and 400 mg kg-1 b.wt. showed generalized congestion, haemorrhage and degenerative changes in the kidney and liver. Also increased intestinal goblet cells, stomach epithelium desquamation, pneumonia, haemorrhage, neuronal degeneration and vaculation of the brain were evident. The group of rats received 50 mg kg-1 b.wt. of potassium bromate was not affected compared to the control.
  Rehab Omer , Afaf I. Abuelgasim and B. Elmahdi
  Twenty four Wistar albino rats were divided into 4 groups and treated orally with potassium bromate at doses of 0, 50, 100 and 200 mg kg-1 body weight (b.wt.) for 21 days. Rats received 200 mg kg-1 b.wt. died within 18 days. A significant reduction in Hb, PCV and MCHC values were observed in animals received 200 mg kg-1 b.wt. in the second week while no changes occurred in the groups treated with 50 and 100 mg kg-1 b.wt. The activity of alanine transaminase (ALT) was significantly increased in rats received 100 and 200 mg kg-1 b.wt. of potassium bromate from the first week, while total protein and albumin were significantly decreased from the first week in animals treated with 200 mg kg-1 b.wt. and the second week at the dose 100 mg kg-1 b.wt. Histologically liver degeneration and haemorrhage was evident in the groups treated with 100 and 200 mg kg-1 b.wt. The dose of 50 mg kg-1 b.wt. did not cause any changes compared to the control.
  B. Elmahdi and S. M. El-Bahr
  Thirty-two rats were divided into four groups (8 rats/each) named as 1, 2, 3 and 4. Group 1 kept on basal diet and served as a control group. Whereas, group 2 kept on the basal diet mixed with 1% cholesterol (high cholesterol diet). Groups 3 and 4 kept on the high cholesterol diet mixed with Fenugreek seed powder 5 and 10%, respectively. Total cholesterol, low-density lipoprotein cholesterol (LDL-c) and alanine transaminase (ALT) activity were significantly increased (32.4±0.2; 12.2±1.5 mg dL-1; 26.5±0.6 IU L-1) whereas, high-density lipoprotein cholesterol (HDL-c) concentration was decreased significantly (11.9±1.6 mg dL-1) in rats fed high cholesterol diet compared to control group (28.1±0.1; 6.0±1.3; 22.7±0.4; 13.9±1.5), respectively. Inclusion of both concentrations of Fenugreek in high cholesterol diet reduced serum total cholesterol (30.5±0.1; 29.5±0.5) and ALT activity (22.1±0.5; 21.7±0.7), respectively compared to rats fed high cholesterol diet and control groups. Histopathological findings revealed fatty changes in liver of rats fed high cholesterol diet which recovered by dietary supplementation of Fenugreek seed powder. Only, inclusion of lower concentration of Fenugreek in diet of rats fed high cholesterol reduced LDL-c concentration (6.2±1.2) and increased HDL-c concentration (15.0±1.0) compared to rats fed high cholesterol diet and the control group. Conclusively, inclusion of low dose of Fenugreek (5%) in ration of rats was recommended than the high dose (10%).
  B. Elmahdi , M.A. Al-Omair , A.A. El-Bessoumy and S.M. El-Bahr
  The stimulation of oxidative stress and lipid peroxidation by acrylamide has been extensively documented. However, the effect of acrylamide on glycolytic enzymes has not been completely elucidated. The present study investigated the effect of acrylamide exposure on activities of serum and hepatic glycolytic enzymes namely, pyruvate kinase, glyceraldhyde-3-phoshate dehydrogenase, phosphofructokinase, hexokinase and α-glucosidase in rabbits. In addition, the protective effect of garlic (Allium sativum) against acrylamide toxicity as reflected on glycolytic enzyme activities has been estimated. Rabbits were exposed to acrylamide dissolved at a concentration of 0.03% (w/v, corresponding to 4.2 mM acrylamide) in distilled water with or without diet containing 1.5% of garlic powder for 42 days. Acrylamide administration reduced the activities of all investigated glycolytic enzymes in serum and liver tissues of rabbits. However, administration of garlic powder with acrylamide significantly attenuated the reduction of activities of these enzymes. In conclusion, the present study emphasized the role of garlic as a potential adjuvant therapy to attenuate acrylamide toxicity in rabbits.
  Afaf I. Abuelgasim , E.A. Omer and B. Elmahdi
  The role of Nigella sativa (N. sativa) in the prevention of liver damage induced by carbon tetrachloride (CCl4) was investigated. Twenty five Wister albino rats were allocated into 5 groups named as A, B, C, D and E. Group (A) was given paraffin oil, group (B) was given dimethylsulfoxide, group (C) was given CCl4 to induced hepatotoxicity, group (D) and (E) were administered with CCl4 together with 250 and 500 mg kg-1 body weight (b.wt.) methanolic extract of N. sativa which was dissolved in dimethylsulfoxide, respectively. Rats were scarified after 10 days. There was an increase in the body weights of the control groups A and B at a rate of 2%. However, the body weights in group C, D and E were reduced by 10.3, 9.3 and 10.3%, respectively. There were no significant changes in the blood picture between the control groups and the treated ones on day 10. The mean plasma ALT, AST and ALP were found to be significantly higher in both CCl4 and N. sativa treated groups compared to the controls, but the increase was less in the groups which were treated with N. sativa methanolic extract with CCl4. The bilibrubin concentration was raised from 0.2 to 0.7 in the group treated with CCl4 and to 0.6 and 0.4 in those treated with 250 and 500 mg kg-1 b.wt. of N. sativa methanolic extract. The histopathological changes in the livers of the group treated with CCl4 exhibited severe centrilobular vacuolation and congestion but in the groups treated with 250 and 500 mg kg-1 b.wt., these changes were to a lesser extent.
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