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Articles by B. Bayala
Total Records ( 2 ) for B. Bayala
  B. Bayala , P.B. Telefo , I.H.N. Bassole , H.H. Tamboura , R.G. Belemtougri , L. Sawadogo , B. Malpaux and J.L. Dacheux
  Testis histology and sperm parameters were used to evaluate the antispermatogenic effect of Leptadenia hastata aqueous extract in male Wistar rats. 100, 200, 400 and 800 mg kg-1 of Leptadenia hastata aqueous extracts were orally administered during 60 consecutive days. L. hastata aqueous extract did not have significant (p>0.05) effect on body, testis and epididymis weights. Testes histology of rats treated with the plant extract showed the decrease of Leydig cells number and the spermatogenesis was been influenced with high doses of L. hastata aqueous extracts. Some sperm parameters as path velocity, progressive velocity, straightness, linearity and motility of spermatozoa were been significantly (p<0.05) decreased. The treated rats with the different amount of L. hastata aqueous extracts showed a significant (p<0.01) reduction in the number of sperm in the testis and the cauda epididymis. Even if its not significant, the extract showed a decrease of testes, epididymis weights and a rarity of Leydig cells. These results confirm the antiandrogenic effect of L. hastata and the claims of breeders that the consumption of the leaves of L. Hastata reduced the fertility of their animals.
  B. Bayala , M.T. Pellicer-Rubio , I.H.N. Bassole , R. Belemtougri , H.H. Tamboura and B. Malpaux
  The present study investigated the effect of aqueous extracts of Leptadenia hastata on male reproductive function. For acute toxicity nine groups of 6 male mice received orally, respectively 50, 100, 200, 500, 1000, 1500, 2000, 3000 and 4000 mg kg-1 of L. hastata aqueous extracts. The results showed the non toxic effect of L. hastata aqueous extracts. Rat weight gain and adrenals weight did not have significantly change. Seminal vesicles, prostate, levator ani plus bulbocavernosus muscles (LABC), cowpers glands, coagulant’s glands weights were significantly decreased with 200, 400, 800 mg kg-1 compared with controls. The serum testosterone level, the fructose and protein content of seminal vesicles and prostate were also significantly decreased with 200, 400, 800 mg kg-1 compared with the controls. Total protein, total cholesterol, HDL cholesterol, blood sugar and hematocrit on blood and serum did not have significantly change. Overall, these results indicate the anti-androgenic effect of L. hastata aqueous extract by Hershberger assay.
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