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Articles by B Guo
Total Records ( 5 ) for B Guo
  B Guo , B. E Perron and D. F. Gillespie

Structural equation modelling (SEM) is serving an increasingly important role in developing knowledge for the social work profession. Numerous advances have made the software more user-friendly, enabling users to conduct analyses without fully understanding the underlying assumptions or the implications from their analytic decisions. Unlike other fields, there have not been any published reviews in social work research that systematically describe and critique the use of SEM. This study systematically reviewed how SEM is used in social work research and the extent to which it reflects best practices. Thirty-two articles from top-ranked social work journals published from 2001 to 2007 were examined. Of the different types of SEM, the most commonly used was confirmatory factor analysis. Strengths of the research reviewed included examining models and measures not previously tested empirically and generating new insights into old topics through the use of SEM. Weaknesses included significant model modifications without theoretical justification or substantive interpretations. Suggestions are offered for improving applications of SEM in social work research. Specifically, we encourage social work researchers to test competing models, to make model modifications only when theoretically justified, to detail the process of making modifications and to use estimation procedures appropriate to the data.

  Y Gao , Y He , J Ding , K Wu , B Hu , Y Liu , Y Wu , B Guo , Y Shen , D Landi , S Landi , Y Zhou and H. Liu

Hepatocellular carcinoma (HCC) is the fifth most common malignancy caused by environmental and genetic factors. MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. They participate in diverse biological pathways and function as gene regulators. Genetic polymorphisms in 3' untranslated regions (3' UTRs) targeted by miRNAs alter the strength of miRNA binding, with consequences on regulation of target genes thereby affecting the individual's cancer risk. We have previously predicted polymorphisms falling in miRNA-binding regions of cancer genes. We selected an insertion/deletion (Indel) polymorphism (rs3783553) in the 3' UTR of interleukin (IL)-1 (IL1A) for a case–control study in a Chinese population. With samples from 403 HCC patients and 434 healthy control individuals, strong evidence of association was observed for the variant homozygote. This association was validated in a second independent case–control study with 1074 HCC patients and 1239 healthy control individuals (odds ratio = 0.62; 95% confidence interval = 0.49–0.78). We further show that the ‘TTCA’ insertion allele for rs3783553 disrupts a binding site for miR-122 and miR-378, thereby increasing transcription of IL-1 in vitro and in vivo. These findings suggest that functional polymorphism rs3783553 in IL1A could contribute to HCC susceptibility. Considering IL-1 affects not only various phases of the malignant process, such as carcinogenesis, tumor growth and invasiveness, but also patterns of interactions between malignant cells and the host's immune system, our results indicated that IL-1 may be a promising target for immunotherapy, early diagnosis and intervention of HCC.

  B Guo , X George Xu and C. Shi

The specific absorbed fraction (), defined by the Medical Internal Radiation Dose Committee, is generally applied to evaluate the average absorbed dose in a target organ as a result of radioactive materials deposited in a source organ. This paper reports a new set of values for internal electron emitters ranging from 10 keV to 4 MeV from various internal organs of the mother to the fetus based on three newly developed pregnant female tomographic models, called RPI-P3, RPI-P6 and RPI-P9. The results show a linear log relationship between values and electron energy. The linear log coefficients have been derived and reported. The relationship between values and mean distances between source organs and the fetus were also determined to allow for individual dosimetry. Since the RPI-P models have finer details of human anatomy and more realistic organ volumes and geometries, which follow the latest ICRP reference values, the newly derived values could be used as reference values in determination of the dose to the fetus from internal electron emitters.

  S Ugi , K Shi , Y Nishio , S Shimizu , B Guo , O Sekine , K Ikeda , K Egawa , T Yoshizaki , Y Nagai , D Koya , T Takada , R Torii , H Kimura , A Kashiwagi and H. Maegawa

Protein-tyrosine phosphatase 1B (PTP1B) is a major regulator of insulin sensitivity. We have described a novel action of PTP1B in the induction of sterol regulatory element-binding protein-1 (SREBP-1) gene expression through activation of protein phosphatase 2A (PP2A). PTP1B is anchored to the endoplasmic reticulum membrane via its C-terminal tail. We have previously reported that membrane localization of PTP1B is essential for PP2A activation, which is crucial for enhancing SREBP-1 gene expression in in vitro experiments. In this study, we further investigated the physiological importance of membrane localization of PTP1B in vivo. We found that transient liver-specific overexpression of wild-type PTP1B (PTP1B-WT) using adenovirus-mediated gene transfer was associated with hypertriglyceridaemia and enhanced hepatic SREBP-1 gene expression in mice. However, overexpression of the C-terminal truncated PTP1B (PTP1BCT) failed to increase hepatic SREBP-1 expression or serum triglyceride levels, despite causing insulin resistance. Our results indicate that activation of PTP1B in the liver could induce hypertriglyceridaemia and that anchoring of PTP1B to the membrane is crucial for its action.

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