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Articles by Azura Amid
Total Records ( 2 ) for Azura Amid
  Ademola Monsur Hammed , Tawakalit Tope Asiyanbi-Hammed , Irwandi Jaswir , Azura Amid and Md. Zahangir Alam
  This study investigates effect of drying method on anti-inflammatory properties and composition of water soluble extracts obtained from brown seaweed, Turbinaria turbinata. T. turbinata was air-oven dried (50°C for 24 h) and freeze dried prior to extraction with water to obtained crude water extract. The crude extracts were partitioned into polyphenol and polysaccharide fractions. Method of drying did not affect the yield of water soluble components. Composition analysis revealed that extracts obtained from freeze dried biomass contain higher total sugar, uronic acid and polyphenol content, except in crude extract where oven dried matter was higher in total sugar and uronic acid content. Anti-inflammatory potential of the extracts was investigated using inhibition of nitric oxide synthesis in RAW 264.7 macrophage cell line. Although, all extracts reduce secretion of Nitric Oxide (NO) differently, percentage NO inhibition between polyphenol fractions of freeze dried and oven dried sample was not significant. Freeze drying retain anti-inflammatory activities of polysaccharide fraction compared to oven drying. Temperature used during oven drying did not cause damage to bioactive compounds in polyphenol fraction of the seaweed. Therefore, either of the two drying methods can be used for dehydration of seaweed but freeze drying is preferred over oven drying when targeting polysaccharide.
  Azura Amid and Gareth J. Warren

Reasons: Dr. Glenn Thorlby, Plant Molecular Biologist pointed out that Azura Amid presented very initial results in this paper and all data presented without getting permissions from the Institute where the research was conducted.

Dr. Glenn Thorlby also pointed out that publication of this work causes serious damage to the careers of other group members who were involved in this (and subsequent) work who are not acknowledged in this publication. This is particularly the case since, I presume in order to ensure publication; the author has included results she knew to be a result of sample mix up!

This aspect of the work was repeated by some of the author’s former colleagues to ensure legitimate results were obtained. This had considerable costs both financial and in terms of time commitment. These investments to correct the author’s mistakes are pointless if the author is allowed to knowingly publish the incorrect data. It also prevents the publication of additional information which was obtained after the author departed the lab which builds on the interpretation of the corrected data.

The journal information states that the “approval of the necessary institution” is necessary to publish work carried out in other labs. This was not sought, and would not have been given, since considerable additional efforts had been made to clarify and expand the results obtained by the author involving several additional authors.

To clear up whether permission was sought I have contacted Prof. P. Bramley, Head of Department, at Royal Holloway where this work was carried out. He has informed me: I have no knowledge of this paper from Azura and have had no contact with her for many months. She has never told me of her plans to publish this work and so the College most definitely did not agree to its submission. It sounds to me that you have a justifiable reason to make a complaint to the journal. Dr. Glenn also pointed out that Most worrying is the inclusion of data which the corresponding author knows to be incorrect. Before the corresponding author finished her Ph.D., on which she has based the manuscript, it was established that the micro-array samples she describes were unfortunately mixed up. The author and another Ph.D. student, in a collaborative project, prepared and sent away samples from a number of different mutants. Later PCR analysis showed that theses samples were not correctly labelled and contained mixed material contaminated with RNA from several different mutants in each tube. The data from them was not reliable. This was later confirmed when the experiments were repeated properly by a post-doc in the lab. The results in the paper incorrectly finding changes in gene expression in warm grown plants that were in fact found in cold treated plants. Although the appropriate section is so badly written it is difficult to tell for sure what the author is concluding.

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