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Articles by Azadeh Andisheh Tadbir
Total Records ( 2 ) for Azadeh Andisheh Tadbir
  Azadeh Andisheh Tadbir , Bita Geramizadeh and Hoda Ranjbaran
  Odontogenic lesions have different and controversial behavior from same lesions in other sites of body. These controversies insist the need of further studies about the nature and behavior of these lesions. The aim of the present study was to investigate the stromal and epithelial expression of CD10 in different odontogenic lesions. In this study 80 odontogenic lesions were evaluated: 29 Unicystic Ameloblastoma (UA) (consists of 5 mural , 24 luminal and intraluminal type) , 11 solid ameloblastoma (SA) , 20 odontogenic keratocysts(OKC) and 20 dentigerous cysts were reviewed by IHC for CD10 staining. Ameloblastoma demonstrated higher number of epithelial CD10 positive cells (9.9±2.1) than UA (4.5±1.4) and dentigerous cysts (2.05±1.5). There was no significant difference in the CD10 expression between OKCs (8.7±2.2) and solid ameloblastomas but significant difference was seen between OKC and UA. Stromal expression of CD10 was seen in 90.9% of solid ameloblastoma and mean percentage of stromal CD10 expression was 14.8±5.5. Cd10 stromal expression showed a statistically significant difference between different groups except SA and OKCs. In conclusion the results of this study propose that high expression rate of CD10 might be one of the reasons for aggressive behavior of ameloblastoma and high recurrence rate of OKC and reinforce the classification of OKC as an odontogenic tumor.
  Soheil Pardis , Azadeh Andisheh Tadbir , Zohreh Jafari Ashkavandi , Ali Dehghani Najvani , Mohammad Javad Ashraf and Hoda Ranjbaran
  To investigate the expression of CDK6 in salivary gland tumors. In this study, 59 samples of salivary gland tumors from Khalili Hospital pathology archive, including 19 cases of pleomorphic Adenoma, 14 cases of Mucoepidermoid Carcinoma and 19 cases of Adenoid Cystic Carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by Immunohistochemistry (IHC) for CDK6 staining. CDK6 expression in normal salivary gland was limited to the cytoplasm of ductal cells, but in tumoral tissues was both nuclear and cytoplasmic. Mean percentage of CDK6 staining in the tumoral group (17.38±21.25) was significantly higher than the normal group (1.1±0.99). So, we recognized a higher expression of this marker in tumoral lesions than in normal tissues (p = 0.021). But there wasn’t any statistically significant difference between expression of CDK6 in different types of tumors (p = 0.2). This study demonstrated that over expression of nuclear CDK6 and the dysregulation of PRb pathway play a role in the oncogenesis of salivary gland tumors.
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