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Articles by Aysel Kukner
Total Records ( 2 ) for Aysel Kukner
  Aysel Kukner , Jale Oner , Hakan Oner and Enver Ozan
  The aim of this study was to investigate effect of the vitamin E on changes in Bax and Bcl-2 expression in the rat testes during immobilisation stress. The animals were divided into three groups. The rats in group I were immobilised for 6 h on 5 consecutive days. The rats in group II were daily injected vitamin E (100 mg kg-1) for 5 days during immobilisation. Control rats were allowed to move freely. The percentage of Bax immunpositive spermatogonia in stress group was significantly higher than those in control groups (p<0.05) but Bcl-2 was not significantly (p>0.05). The percentages of Bax and Bcl-2 immunpositive cells in the vitamin E treated group was decreased than the immobilization stress group. It was observed that Bax and Bcl-2 expression were peak level (+) in the spermatogonia of the control group. In this group, Bax and Bcl-2 expression were not determined mostly in the seminifer tubules. Neither Sertoli cells nor spermatids showed immunoreaction. Bax immunoreactivity was observed at strong level (+++) in both spermatogonia and intersititial cells of immobilised rats. In this group, Bcl-2 protein was expressed at peak level (+) in the spermatogonia. Bax expression was decreased in vitamin E treated group and at peak level (+) immunreaction was showed in the spermatogonia and intersitisyal cells. Findings of this study show that the immobilisation stress increases apoptosis and vitamin E decreases Bax and Bcl-2 expression that are apoptosis-releated proteins in the immobilised rat testes.
  Aysel Kukner , Neriman Colakoglu , Candan Ozogul , Mustafa Naziroglu and Tulin Firat
  Diabetic nephropathy is a serious complication of diabetes mellitus. Oxidative stress has been suggested to play a key role in the pathogenesis of diabetic nephropathy. Vitamins C and E play important roles in the antioxidant defense system. It is likely that both vitamins act in a synergistic manner, with vitamin E primarily being oxidized to the tocopheroxyl radical and then reduced back to tocopherol by vitamin C. The purpose of the study was to determine the effects of supplementation of Vitamins C and E (VCE) on diabetic rat kidney. Adult female Wistar rats were used in the study. The animals were divided into three groups. Group I: the control group; Group II: diabetic group, streptozotocin (40 mg kg-1) was administered group; Group III: diabetes + VCE group, received a diet containing a combination of ascorbic acid and dl-α-tocopheryl acetate per kg of feed. Rats were killed on 21st day and renal tissues were taken and fixed in 2.5% glutaraldehyde solution for electron microscopic examination. When compared with the control group, congestion of the glomerular capillaries, increased mesangial cells and distinct mesangium, shortened podocyte processes and disappearance of filtration slit pore of diabetic rat kidney were observed. In the group treated with VCE, glomerular changes were less distinct than the diabetic group. Lengths of the pedicles were similar to the control group. VCE reduced the changes in the glomerular structures due to diabetes.
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