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Articles by Ayoob Rostamzadeh
Total Records ( 6 ) for Ayoob Rostamzadeh
  Abdolmajid Taheri , Daryoush Fatehi , Mohsen Mohammadi and Ayoob Rostamzadeh
  Apoptosis involves a particular type of cell death that plays an important role in tissue turnover and homeostatic regulation. Remove unwanted cells in multicellular organisms and unicellular organized by this process. Cell apoptosis begins with the production and release of various factors. The effects of apoptosis depend on the environment in which is occur programmed cell death. Apoptosis in some cells also causes release of various factors such as cytokines and subsequently mediated activation of other protein mediators of immune and inflammatory response. Today, using genes, inducer metabolites and inhibitors involved in of apoptosis, or programmed cell death, can be immune system (the balance between cellular and humoral immune) is directed towards the desired immune response. There are different methods for detection of apoptotic cells and each of these methods alone cannot be used as the criterion of apoptosis. The activation of caspases also is a marker for cellular damage in diseases. Caspases as an indicator is specific apoptosis therefore determine the activation of caspase can be used to differentiate between necrosis and apoptosis. Molecular imaging is ideally suited to measuring early response by quantifying cellular metabolism, proliferation and apoptosis, activities altered early in treatment. There are now several possible Magnetic Resonance Imaging (MRI) based approaches for detecting apoptosis, in particular tumor apoptosis, which have the potential to be translated into clinical application. Detection of cellular lipid droplet accumulation, using localized Magnetic Resonance Spectroscopy (MRS) and changes in tissue architecture using Diffusion-Weighted Imaging (DWI) has the virtues that they are completely non-invasive and thus could be implemented in the clinical practice now. Potential disadvantages include a lack of specificity for apoptosis and the possibility that they may be limited in detecting relatively low but clinically relevant, levels of cell death. Finally using labeled molecular factors and inducer proteins and also measurement of metabolites by non-invasive medical imaging techniques such as magnetic resonance spectroscopy can be identified the actual mechanisms and pathways of apoptosis as well by manipulated these pathways may be effective in the prevention of diseases such as autoimmune and neurodegenerative disorders.
  Hossien Masoumi , Maryam Anjamshoa , Mohsen Mohammadi , Shirzad Fallahi and Ayoob Rostamzadeh
  Silymarin, a flavonolignan from ‘milk thistle’ (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. In this review, we discuss about its safety, efficacy and future uses in liver diseases. The use of silymarin may replace the polyherbal formulations and will avoid the major problems of standardization, quality control and contamination with heavy metals or bacterial toxins. Silymarin consists of four flavonolignan isomers namely; silybin, isosilybin, silydianin and silychristin. Among them, silybin being the most active and commonly used. Silymarin is orally absorbed and is excreted mainly through bile as sulphates and conjugates. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It acts by antioxidative, anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, immunomodulatory and liver regenerating mechanisms. Silymarin has clinical applications in alcoholic liver diseases, liver cirrhosis, Amanita mushroom poisoning, viral hepatitis, toxic and drug induced liver diseases and in diabetic patients. Though silymarin does not have antiviral properties against hepatitis virus, it promotes protein synthesis, helps in regenerating liver tissue, controls inflammation, enhances glucuronidation and protects against glutathione depletion. Silymarin may prove to be a useful drug for hepatoprotection in hepatobiliary diseases and in hepatotoxicity due to drugs. The non-traditional use of silymarin may make a breakthrough as a new approach to protect other organs in addition to liver. As it is having a good safety profile, better patient tolerability and an effective drug at an affordable price in near future new derivatives or new combinations of this drug may prove to be useful.
  Mohsen Mohammadi , Ardeshir Moayeri , Omar Ghaderi , Hamid Reza Mohammadi and Ayoob Rostamzadeh
  Burn injury has been reported to be an important cause of morbidity and mortality in many countries which leads to a loss of integrity of the skin which protects us from water loss, temperature change, radiation, trauma and infection. The main sources of stem cells that might be used for repair and regeneration of injured skin tissue are Embryonic Stem Cells (ESCs) and adult stem cells. ESCs have a great capacity for self-renewal and pluripotency but their clinical applications are limited because of the political and ethical considerations. Also, ESCs themselves are less suitable for tissue grafting; they do provide the potential to augment physiological healing processes via paracrine mechanisms. Stem cells allows for the possibility of restoring lost or damaged tissue, while their ability to modulation of immune system the wound bed from afar suggests that their clinical applications need not be restricted to direct tissue formation. The clinical utility of stem cells has been demonstrated across dozens of clinical trials in chronic wound therapy; thus, it promotes normal interactions between cell assemblies during the regeneration of burn wounds which prevents the formation of cicatrix or the deformation of tissues. Furthermore, Induced Pluripotent Stem Cells (iPSCs) derived fibroblasts may be an increased production of extracellular matrix proteins that could also increase the rate of wound healing as well as provide opportunities for eventually generating these structures without the risk of immune rejection.
  Abdolmajid Taheri , Hossien Masoumi , Ardeshir Moayeri and Ayoob Rostamzadeh
  Magnetic Resonance Spectroscopy (MRS) is a non-invasive diagnostic and is the neuroimaging method of choice for the noninvasive monitoring of brain metabolism in patients with glioma tumors due to the enormous amount of information it yields regarding the morphologic features of the lesion and surrounding parenchyma. The most prevalent metabolites in the MRS spectrum are N-acetylasparate (NAA), total-Cholinecontaining metabolites (Cho), Lactate (Lac), Mobile Lipids (Lip), Creatine (Cre), Glutamate (Glu), Glutamine (Gln; the glutamate and glutamine signals cannot always be resolved and studies will then refer to their composite Glx peak), Myo-Inositol (mIns), Glycine (Gly), Glutathione (GSH) and 2-Hydroxyglutarate (2-HG). Personalized medicine using MRS can be used an understanding of the various physiological basic and mechanism of the metabolic signatures obtained from different types of tumors, and the specificity of the technique. Finally, establishment basis of physiological characteristics of the metabolites in various types of brain tumors, and the clinical utility of MRS as an additional and confirming diagnostic tool could improvement processes include fact and correct primary differential diagnosis therapeutic planning, and the assessment of response to treatment.
  Abdolmajid Taheri , Mohammad Gharib Salehi , Farhad Naleini , Jamil Abdolmohammadi , Ayoob Rostamzadeh and Daryoush Fatehi
  This study evaluated the clinical usefulness of MRI ability in assessment of different stroke satege using routine and advance technique such as T2w, FLAIR, DWI and perfusion MRI. There are four stages of stroke which include hyper acute, acute, sub acute and coronic. Also there are four types of brain hemorrhages like, Epi Dural Hematoma (EDH), Sub Dural Hematoma (SDH), Intracerebral or Cranial Hematoma (ICH) and Sub Arachnoid Hematoma (SAH). Although, CT is a diagnostic routine for stroke but MRI can be valuable diagnostic imaging for representing information particularly in connection with hemorrhagic infarcts give us. Multimodal imaging provides information that is useful for diagnosing ischemic stroke, selecting appropriate patients for thrombolytic therapy and predicting the prognosis of ischemic stroke.
  Mohammad Jafar Rezaie , Sayed Mohammad Hosseinipanah , Ayoob Rostamzadeh and Damoon Mohamadian Poor
  Reconstruction of critical bone defects is one of the most important issues in medical science where the use of materials with properties osteoconduction, osteoinduction and osteogenic needs. In some studies, the posetive effect of platelet rich plasma and other studies have reported no effect on the healing of bone defects. Current study also aimed to assess the restoration of critical bone defects treated with platelet rich plasma, nanogel bone scaffold and allograft alone an in combination. In this experimental study, 50 adult New Zealand white rabbits were randomly divided in five groups. After general anesthesia, under sterile conditions to help trephin drill hole size 8×12 mm in the femor of lateral condyl each of the animals created. In control group (G1) the defect was filled by blood clot only. In G2, G3 and G4, inside cavity were replaced nanogel scaffold, nanogel scaffold+PRP and nanogel scaffold +PRP, +FDBA, respectively. At weeks 2, 4 and 8 after surgery, three animals from each group were randomly selected and then sampling of the defect, the bone repair techniques using histological and histomorphometric parameters. Data were analyzed by Kruskal-Wallis and Mann-Whitney U tests and p>0.05 was considered significant. The minimum amount of bone formation between groups was belonged to the control group. The mean bone parameters were significantly different in the second week (p<0.05) and the average of all bone parameters in the G1 and G2 were zero in this week. In the fourth week of the fourth group, mean resorption surface was (83.04±2.65) and mean bone volume was (81.83±4.60). The mean bone parameters were significantly different in the fourth week (p<0.05). In the eighth week of the fourth group, mean resoption surface was (81.61±1.81) and mean bone volume was (83.20±1.40). The mean bone parameters were significantly different in the eitghth week (p<0.05). The results of this study showed that the bone grafts combined with PRP compared with none combining them with PRP increases the healing rate of critical bone defects. Also, healing rate of bone defects using allograft is more than with nanogel scaffold.
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