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Articles by Aylin Mutlu
Total Records ( 3 ) for Aylin Mutlu
  Okan Zaefer Yeiel , Aylin Mutlu and Orhan Buyukgungor
  Two copper(II) complexes of 2,3-pyrazinedicarboxylate (pzdca) with N,N’-dimethylethylenediamine (dmen), [Cu2(pzdca)2(H2O)2(dmen)2] · 6H2O (1) and 1,10-phenanthroline (phen), [Cu(pzdca)(phen)2] · 5.5H2O (2), have been prepared and characterized by elemental analyses, IR, UV/vis, magnetic measurement and single crystal X-ray diffraction. The complexes crystallize in the monoclinic space group P21/c and triclinic space group P1, respectively. In both complexes the copper coordinates pyrazine nitrogen and carboxylate oxygen as a bidentate ligand. The coordination sphere around Cu(II) is completed by two N atoms from dmen and four N atoms from phen groups and one axial position occupied by the carboxyl O atom from the symmetry related molecule in 1. The coordination sphere should be described as a distorted octahedral and (5 + 1)-geometry in 1 and distorted octahedral geometry in 2. While 1 shows a first dimeric arrangement, 2 is a monomer. The thermal analyses show that 1 and 2 decompose completely in four and five step thermal processes at 20-600°C temperature intervals.
  Okan Zafer Yesilel , Aylin Mutlu and Orhan Buyukgungor
  Three novel Cu(II)-pyrazine-2,3-dicarboxylate complexes with 1,3-propanediamine (pen), [Cu2(μ-pzdc)2(pen)2]·2H2O (1), N,N,N,N′-tetramethylethylenediamine (tmen), {[Cu(μ-pzdc)(tmen)]·H2O}n (2), and 2,2′-bipyridine (bipy), {[Cu(μ-pzdc)(bipy)]·H2O}n (3) have been synthesized and characterized by means of elemental and thermal analyses, magnetic susceptibilities, IR and UV/vis spectroscopic studies. The molecular structures of dinuclear (1) and polynuclear (2 and 3) complexes have been determined by the single crystal X-ray diffraction technique. The pyrazine-2,3-dicarboxylate acts as a bridging ligand through oxygen atom of carboxylate group and N atom of pyrazine ring and one oxygen atom of neighboring carboxylate. It links the Cu(II) ions to generate a distorted square pyramidal geometry forming a one-dimensional (1D) chain. Adjacent chains of 1 and 2 are then mutually linked via hydrogen bonding interactions, which are further assembled to form a two and three-dimensional network, respectively. The chains of complex 3 are further constructed to form three-dimensional framework by hydrogen bonding, C–H...π and ring...ring stacking interactions. In the complexes, Cu(II) ions have distorted square pyramidal geometry. Thermal analyses properties and thermal decomposition mechanism of complexes have been investigated by using thermal analyses techniques (TG, DTG and DTA).
  Hakan BOZCUK , Mustafa OZDOGAN , Oktay AYKURT , Fatih TOPCUOGLU , Hasan OZTURK , Deniz EKINCI , Asuman KARADENIZ , Aylin MUTLU and Durmus BURGUCU
  Aim: Urginea maritima (Um) is a plant native to especially Turkey and the Mediterranean area. In this study, we investigated whether Um extract exerted cytotoxicity on cancer cells. Materials and methods: We made various extracts of Um. These extracts in varying concentrations were added to an A549 NSCLC cell culture, alone or with gemcitabine and/or cisplatin. Growth inhibition was tested by the MTT assay and an Annexin V-FITC apoptosis detection kit Results: The onion Um extract (1 μg/mL) was more cytotoxic than cisplatin (1 μg/mL), gemcitabine (1 μg/mL), and leaf Um extract (1 μg/mL) with P < 0.001, P = 0.097, and P < 0.001, respectively. The efficacy of Um extract was further improved by the addition of an antioxidant cocktail to an IC50 value of 0.02 μg/mL. Conclusion: Um extract has been shown for the first time to be a strong candidate for drug development in solid tumors. Our studies continue to further define the specific antitumor compound(s) in this extract.
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