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Articles by Asuman SUNGUROGLU
Total Records ( 2 ) for Asuman SUNGUROGLU
  Aslıhan AVCI , Asuman SUNGUROGLU , İmge B. ERGUDER , Guvem GUMUS AKAY , Erdinc DEVRIM , Pınar OZKAL BAYDIN , Nuray VAROL and Ilker DURAK
  Aims: To investigate the possible effects of aqueous garlic extract on the oxidant/antioxidant status and apoptosis in 32D (wild type mouse myeloid cell = normal) and 32Dp210 (BCR-ABL fusion gene (+) mouse myeloid cell = Chronic Myelocytic Leukemia cells) cell lines. Materials and methods: Aqueous garlic extract (10% w/v) was added into the cell line media with 2 different final concentrations (0.4% and 1%). At 0 h and at 24, 48, and 72 h later, the oxidant (malondialdehyde (MDA) level, and xanthine oxidase (XO) enzyme activity) and antioxidant (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities) parameters were measured in the cell lines. Results: It was observed that the garlic extract caused no change in the XO and antioxidant enzyme activities, but it increased the MDA level in the 32D cell line. However, significant increases were found in the MDA level, XO, and antioxidant enzyme activities in the 32Dp210 cell line treated by the garlic extract. Additionally, it was shown that garlic extract had antiproliferative and apoptotic effects on both cell lines. The most effective apoptotic dose was found to be 0.4% (w/v), and at this concentration the death risk of the 32Dp210 cell line was calculated at 2.08 times higher than that of the 32D cell line. Conclusion: It has been suggested that garlic directly causes oxidant stress in the 32D cell line owing to its own oxidant ingredients, and that the oxidant stress created by garlic in the 32Dp210 cell line might occur through increased XO activity and/or its oxidant ingredients. Additionally, antioxidant enzyme activities were found to increase in the 32Dp210 cell line; it would seem that this compensatory change could not prevent the oxidant stress created. We think that the oxidant potential of garlic extract might play a part in its possible anticancer potential, previously supposed by several investigators.
  Oya Sena AYDOS , Aslıhan AVCI , Tulin OZKAN , Aynur KARADAG , Ebru GURLEYIK , Buket ALTINOK and Asuman SUNGUROGLU
  Aim: Plant-based diet supplements help the prevention and therapy of several kinds of cancer because they contain micronutrients, a class of substances that have been shown to exhibit chemopreventive and chemotherapeutic activities. In the present study the effects and oxidant/antioxidant status of aqueous and ethanol extracts of wheatgrass were tested in human chronic myeloid leukemia CML (K562) cell line. Materials and methods: K562 cell lines were treated with 10% (w/v) concentration of aqueous and ethanol wheatgrass extracts. Cytotoxicity and apoptosis were determined morphologically and by MTT and DNA laddering. MDA level and CAT, SOD, and ADA activities of the cell lines were measured. Results: Both preparations inhibited the growth of leukemia cells in a time-dependent manner. The most apoptotic and antiproliferative effect was seen in the cell line treated with aqueous extract at 48 h (P < 0.001). Increases in MDA level and CAT and SOD activities were observed. Conclusion: Wheatgrass extract has an antioxidant activity, inhibits proliferation of leukemia cells, and induces apoptosis; thus, this finding may represent a novel therapeutic approach for the treatment of CML.
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