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Articles by Asmah Rahmat
Total Records ( 6 ) for Asmah Rahmat
  Farrawati Sabli , Maryati Mohamed , Asmah Rahmat , Halijah Ibrahim and Mohd Fadzelly Abu Bakar
  In this study, total phenolic and flavonoid contents as well as antioxidant properties of methanolic extracts of rhizomes and stems of four Zingiberaceae (Etlingera belalongensis, Etlingera velutina, Zingiber vinosum and Zingiber pseudopungens) were investigated. Evaluation of antioxidant activity was conducted using 1,1-diphenyl-2-picrylhydrazyl free radical-scavenging (DPPH) assay, 2-2’-azinobis-3-ethylbenzothioazaline-6-sulphonate radical scavenging (ABTS) assay and Ferric-Reducing Antioxidant Power (FRAP). The results showed the total phenolic and total flavanoid contents were in the range of 5.3-41.7 mg gallic acid equivalent/g and 1.09-5.86 mg catechin equivalent/g of dry sample, respectively. The antioxidant activities of the extracts as assessed by using DPPH and FRAP assays were strongly correlated with all phytochemical tested (p<0.05). As a conclusion, selected tropical gingers found in Sabah investigated in this study can be developed as natural antioxidant agents.
  Asmah Rahmat , Rozita Rosli , Wan Nor I`zzah Wan Mohd. Zain , Susi Endrini and Huzaimah Abdullah Sani
  Lycopene is one of the major carotenoids in the diet and is believed to have a number of health benefits including anticancer properties. This investigation was conducted with the aim of screening the potential anticancer properties of pure lycopene and of both extracted lycopene and juices from watermelon and papaya. Two different types of human tumor cell lines, HepG2 (liver cancer cell line) and MDA-MB-231 (breast cancer cell line) were used for the evaluation of cytotoxicity effects. Chang liver cell line that is the transformed cell for the liver was used for comparison. The cells treated with pure lycopene, extracted lycopene and juices from both watermelon and papaya were maintained and incubated at 37°C in 5% CO2 for five days. The Microculture Tetrazolium salt (MTT) assay was carried out in this investigation, to determine the cell viability. Pure lycopene was found to cause 50% cell death (IC50) of HepG2 cells at a concentration of 22.8 μg ml-1, while papaya juice at a concentration of 20 mg ml-1. In the case of MDA-MB-231 cells, the IC50 of the watermelon was 11.3 mg ml-1. The other samples including extracted lycopene samples did not show any effect in the cell viability. The findings of this study showed that pure lycopene and papaya juice may have anticancer properties upon liver cancer cell line (HepG2), while watermelon juice had anticancer properties against breast cancer cell line (MDA-MB-231). The juices seemed to be more effective than the extracted lycopene samples in inhibiting cancer cell growth.
  Ling Jing Jing , Mohd Fadzelly Abu Bakar , Maryati Mohamed and Asmah Rahmat
  The aim of this research was to determine the potential of Boesenbergia species collected from Sabah rainforest as anticancer remedy. This research was done to Boesenbergia rotunda, B. pulchella, B. pulchella var attenuata and B. armeniaca crude extracts on the in vitro proliferation of hormone-dependent breast cancer (MCF-7), non-hormone dependent breast cancer (MDA-MB-231), ovarian cancer (CaOV3), colon cancer (HT-29) and cervix cancer (Hela) cell lines. The effects of the four Boesenbergia species (methanol extracts of leaves, stem and rhizome part) on the proliferation of MCF-7, MDA-MB-231, CaOV3, HT-29 and Hela cell lines were measured using (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) MTT assay. The crude extracts with IC50 value less than 100 μg mL-1 were subjected to cell cycle analysis by using flow cytometry for DNA content determination. B. rotunda as positive control showed significant inhibitions towards all the cancer cell lines tested with IC50 ranging from 51.0±0.01 to 71.0±1.41 μg mL-1. The remaining Boesenbergia species only showed positive cytotoxicity activities against MCF-7 cell lines especially B. pulchella var attenuata with IC50 value 93.0±2.83 μg mL-1 and B. armeniaca with 94.5±0.71 μg mL-1. In cell cycle analysis, B. rotunda crude extract arrested cell at sub-G1 phase while B. pulchella var attenuata arrested cell at G2/M phase. From this study, it can be concluded that only B. pulchella var attenuata and B. armeniaca were effective against cellular proliferations of MCF-7. However, both species were not as effective as B. rotunda.
  Fatimah Ghazi , Asmah Rahmat , Zaitun Yassin , Nurul Shazini Ramli and Nurul Amira Buslima
  Ficus carica grows in tropical and subtropical regions of Saudi Arabia. The current study was conducted to evaluate the proximate analyses, minerals, alpha-tocopherol and vitamin C contents, and to investigate the antioxidant capacities of aqueous and methanolic extracts prepared from Ficus carica leaves. The antioxidant capacities in the forms of DPPH and FRAP were evaluated by spectrophotometric methods. Alpha-tocopherol and vitamin C contents were determined by using a high-performance liquid chromatography (HPLC)-UV method. Total phenolic content was determined by using the Folin-Ciocalteau method. The results indicated that TPC, DPPH and FRAP values were higher in methanolic extract of big Ficus carica leaf (412.37±57.9mg GAE/100 g, 63.29±2.51% and 131.39±13.96 mmol Fe2+/100 g) in comparison to small leaf. Total phenolics were however higher in aqueous extract compared to methanolic. The results clearly demonstrate that these extracts have antioxidant capacity though there was no significant correlation between total phenolic content and antioxidant activity. Also, nutritional composition of Ficus carica leaves showed that they are good sources of minerals. Ficus carica leaf is therefore a rich source of polyphenols and has high antioxidant properties.
  Mohammed Ellulu , Asmah Rahmat and Yehia Abed
  Overweight and obesity are worldwide public health issues which are defined as abnormal or excessive fat accumulation. WHO reported that there are one billion overweight people in the world, 300 million of whom are obese. Total body and abdominal obesity have well-known associations with all-cause mortality, morbidity and disability, resulting in unhealthy life-years with poor quality of life and increased health care costs. The increased measure of BMI more than 25 and 30 kg/m2 will result in overweight and obesity respectively, while waist circumference is important for determining the central obesity. All Arab Countries including Palestine referred as the Eastern Mediterranean Region according to WHO. Palestine has many reports about increasing levels of Non Communicable Diseases (NCDs) like diabetes, hypertension, stroke and heart diseases which linked directly with overweight and obesity. The death conditions in Palestine due to NCDs are also escalated over years. However, the number of studies and reports focused on overweight and obesity in Palestine is very little in comparing with the high evidences of NCDs linked to them. The main data was collected from three sources; Governmental, Non-governmental organizations and individual studies from Master Thesis. In other way, the data collected divided into three categories; the first one designed mainly to evaluate overweight and obesity, the second had assessed overweight and obesity as a secondary objective in the way for evaluating nutritional status and the last one had the assessment within the context of the study. The results revealed data collected among vulnerable groups in both sexes. Most of studies indicated high measure of overweight and obesity among older adults rather than young adults. Finally; Palestine still in need for more studies to include all age groups and different cities.
  Mohammed S. Ellulu , Asmah Rahmat , Yehia Abed , Suha Baloushah , Ismail Patimah and Huzwah Khazaai
  To assess the differences on inflammatory and metabolic indicators between pre-menopause and post-menopause women among hypertensive and/or diabetic type-2 women. A total of 236 obese women included in the study have chosen from Primary Health Care Centers in Gaza City, Palestine, through a cross-sectional study. Selection depended on health status hypertensive and/or diabetic type-2 (HT, T2DM, HT+T2DM). In HT group, post-menopause women had significant higher values than pre-menopause women on TC (200±47 vs. 172.5±55 mg dL–1, p<0.01) and TG (166±89 vs. 120.5±82 mg dL–1, p<0.01). In T2DM group, post-menopause women had significant higher values than pre-menopause women on SBP (132±24 vs. 120±20 mm Hg, p<0.01), TC (213±40 vs. 185±46 mg dL–1, p<0.05) and TG (196±118 vs. 136±64 mg dL–1, p<0.05). Finally, in HT+T2DM group, post-menopause women had significant higher value than pre-menopause women on SBP (144±21 vs. 133±14 mmHg, p<0.05), TC (214±54 vs. 181±55 mg dL–1, p<0.05), TG (231±83 vs. 158±85 mg dL–1, p<0.05), IL-6 (2.32±1.34 vs. 1.71±1.45 pg mL–1, p<0.05) and BMI (36.48±7.1 vs. 32.18±5.6 kg m‾ 2, p<0.05). Post-menopause women diseased of HT and T2DM accompanied with higher rates of BMI are at risk for developing inflammatory and metabolic morbidities.
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