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Articles by Asmaa Hegazy
Total Records ( 2 ) for Asmaa Hegazy
  Amira F. Barakat , Asmaa Hegazy , Raghda E. Farag , Azza Abdul Baky , Lamiaa F. Arafa and Amal Farouk
  The aim of this study was to examine interferon-gamma (IFN-γ), anti-C1q antibodies, myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) and anticardiolipin antibodies in the serum of biopsy-proven chronic hepatitis C patients before and after interferon (IFN)-alpha and ribavirin therapy to address whether or not viral clearance is related to these biomarkers and to explore a possible association between the pattern of these immune response parameters with the virological and biochemical status of Hepatitis C Virus (HCV). The serum levels of IFN-γ, anti-C1q, myeloperoxidase ANCA and anticardiolipin antibodies were assayed on 64 patients with chronic hepatitis C virus infection before and 48 weeks after treatment with pegylated IFN-α plus ribavirin and compared with sera from 20 normal control subjects. Serum levels of ICN-γ, anti-C1q, myeloperoxidase ANCA and anticardiolipin antibodies were significantly higher in HCV patients in comparison to healthy controls (p<0.0001). IFN-γ levels were significantly increased after 48 weeks of antiviral treatment when compared to pretreatment serum levels and it was significantly more elevated in responder HCV patients than non responders. While as, both anti-C1q antibodies and myeloperoxidase ANCA levels were significantly decreased after 48 weeks antiviral treatment in the HCV patients. Moreover, IFN-γ levels (but not other studied biomarkers) in HCV patients correlated significantly with high alanine aminotransferase (ALT) levels as well as with high viral load (r = 0.675, p≤0.05, r = 0.912, p≤0.001, respectively). In conclusion, IFN-gamma might be useful in predicting the clinical outcome of the combination therapy of pegylated-IFN alpha and ribavirin, as well as responsiveness to IFN-alpha-based therapy may be improved by using easily assessed immune response biomarkers such as interferon gamma, anti-C1q antibodies. Furthermore, early treatment in HCV patients with multiple serological abnormalities will prevent further autoimmune response which eventually could prevent marked extrahepatic complications.
  Amany A. Mousa , Mohamed Ghonem , Asmaa Hegazy , Azza A. El-Baiomy and Amany El-Diasty
  The present study was designed to investigate the frequency of thyroid dysfunction in Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) and whether these dysfunctions could be an additional risk factor for the development of cardiovascular diseases. Our study included 132 SLE patients (128 females, 4 males) and 217 RA patients (174 females, 43 males). All patients underwent clinical examination and tests for thyroid function and thyroid autoimmunity (antithyroglobulin or Tg and antiperoxidase or TPO antibodies). One hundred and twenty (90 females, 30 males) from the same geographical area, acted as controls. TPO abs were found in 26 SLE patients (19.7%), 22 RA patients (10.1%) and 7 controls (5.8%) while Tg abs were found in 11 (8.3%) SLE, 13 (6%) RA and 2 controls (1.6%). Abnormal thyroid functions were found in 21 (15.9%) SLE, 18(8.3%) RA patients compared to 5 (4.2%) controls (p<0.05). Of those patients with thyroid dysfunction, 17 SLE, 12 RA and 4 controls were positive for TPO abs. The most common abnormality was clinical hypothyroidism (8.3 SLE, 4.1% RA patients) then subclinical hypothyroidism (5.3 SLE, 1.8% RA patients). Subclinical hyperthyroidism was found in 2 (1.5%) SLE and 4 (1.8%) RA patients. Hypothyroid patients had significantly higher blood pressure, low density lipoprotein, C-reactive protein, lipoprotein (a) anti TPO and anti TG abs than euthyroid patients. In conclusion, SLE and RA patients had higher prevalence of anti-thyroid antibodies and hypothyroidism, compared to our normal population. SLE and RA patients with hypothyroidism are at increased risk for CVD compared to those with normal thyroid function.
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