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Articles by Asmaa Magdy Zaazaa
Total Records ( 2 ) for Asmaa Magdy Zaazaa
  Nadia Noble-Daoud Aniss , Asmaa Magdy Zaazaa and Mohamed Rabie Abdalla Saleh
  Background and Objective: Rheumatoid arthritis (RA) is the commonest form of chronic inflammatory autoimmune disease with unknown etiology that attacks joint tissue for unknown reasons and is influenced by genetic as well as environmental factors. The present study was aimed to investigate the anti-rheumatic effect of platelets rich plasma (PRP) and intra gel hyaluronic acid (HA) on complete freund's adjuvant (CFA) induced RA. Materials and Methods: A total of 32 adult male rats were categorized into 4 groups (n = 8): Normal control received vehicles only, RA group received CFA (0.1 mL) injected in the right hind paw, PRP group (50 μL) intra-articularly injected into the right inflamed knee and paw and HA group (50 μL) of HA sodium salt into the inflamed joints. All treatments were administered for 4 weeks. Serum MDA, GSH and GPx levels were investigated using ELISA as oxidative stress biomarkers. Serum CRP, IL-1β, TNF-α, COX-2, ALOX5, MMP-9 and LT-C4 were also determined using ELISA as inflammatory biomarkers. Specific rheumatoid marker COMP and MMP-3 expression levels were detected using qRT-PCR. Histopathological changes in the joint tissues were examined using hematoxylin and eosin (H and E) stain. X-ray was also performed in examining the bone and joints. Results: PRP and HA significantly reduced serum MDA and increased GSH and GPx levels. Tested drugs also significantly reduced CRP, IL-1β, TNF-α, COX-2, ALOX5, MMP-9 and LTC4 serum levels. Administration of PRP or HA normalized COMP and MMP-3 expression levels in CFA-induced RA rats. Histopathological analysis and X-ray of PRP or HA groups showed a gradual reduction in joint damage and cartilage erosion. Conclusion: In conclusion, PRP and HA possess antirheumatoid effects in CFA-induced RA rats which is mediated through anti-inflammatory, antioxidant and modulation of COMP and MMP-3 expression levels.
  Asmaa Magdy Zaazaa , Bosy Azmy Abd El- Motelp and Nadia Noble-Daoud Aniss
  Background and Objective: Cisplatin-induced nephrotoxicity is a serious complication that restricts its utilization in cancer treatment. Rutin and alpha-lipoic acid have antioxidant effectiveness, anti-inflammatory efficacy and prevent oxidative stress. Therefore, the current study planned to investigate the potential defensive impacts of rutin and alpha-lipoic acid on cisplatin-induced renal damage in rats. Materials and Methods: Fifty-six adult male Wistar albino rats were randomly divided into seven groups. Rats of group 1: Treated with saline as the control. Group 2: Orally received rutin daily for 2 weeks. Group 3: Rats were orally administered with alpha-lipoic acid (ALA) daily for 2 weeks. Group 4: Rats were intraperitoneal (i.p.) injected with cisplatin to develop the acute renal injury. Group 5: Rats injected with cisplatin then treated orally with RT. Group 6: Rats were injected i.p., with cisplatin then treated orally with ALA. Group 7: Rats injected with cisplatin then treated orally with RT and ALA daily for 2 weeks. Results: The cisplatin administration to rats induced nephrotoxicity associated with a significant increase in serum urea, creatinine, albumin and significantly reduce haemoglobin and red blood cells count. The animal treated with cisplatin showed a significant increase in the level of renal malondialdehyde associated with reduction in the levels of glutathione-s-transferase, glutathione reductase and catalase compared to control group. Moreover, cisplatin treated group recorded significant increase in nuclear factor kappa B, IL-6 and p53 levels compared to control group. Additionally, histopathological examination showed that cisplatin-induced interstitial congestion, focal mononuclear cell inflammatory, cell infiltrate and acute tubular injury. In correlation with the cisplatin group, Rutin and alpha-lipoic acid ameliorated cisplatin-induction increase in serum urea, creatinine, albumin, oxidative stress and inflammation were observed. Moreover, rutin and alpha-lipoic acid showed an enhancement in haematological and histopathological structures. Conclusion: These results indicated that rutin and alpha-lipoic acid showed a protective effect against cisplatin-induced nephrotoxicity in rats.
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