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Articles by Asmaa F. Khafaga
Total Records ( 2 ) for Asmaa F. Khafaga
  Asmaa F. Khafaga and Aida E. Bayad
  Background and Objective: Cisplatin (CIS) is known to cause nephrotoxic effect, depression in erythrocytes (anemia), leukocytes (leukopenia) and platelets (thrombocytopenia) in a dose-dependent manners which limits its clinical use. This study was designed to investigate the efficacy of Ginkgo biloba (GB) extract against hematological and pathological disorders, oxidative stress and nephrotoxicity induced by single or repeated injection cycles of cisplatin in rats. Materials and Methods: Animals were divided into six equal groups (n = 10). Negative and positive control groups (received vehicle, GB 150 mg kg–1, respectively), cisplatin intoxicated groups (received 24 mg kg–1 as a single i.p. injection, or as three repeated injection cycles; each cycles consists of 4 daily low dose 2 mg kg–1 b.wt., followed by 10 days recovery period) and GB preventive groups (received the same treatment as intoxicated groups in concomitant with daily 150 mg kg–1 b.wt., of GB orally, started 5 days before first CIS injection). The possible ameliorative effect of GB was determined on CIS-induce alterations in Relative Kidney Weight (RKW), Blood Urea Nitrogen (BUN), creatinine, blood picture, tissue oxidative parameters, histopathologic and histo-morphometric analysis and quantification of TUNEL positive cells. Results: The study revealed significant increase in RKW, serum creatinine and BUN, renal malondialdehyde (MDA), quantitative and semi-quantitative grading of renal pathology and number of TUNEL positive cells/HPF in CIS intoxicated groups. Moreover, significant decrease was reported in renal glutathione (GSH), Hb concentration, RBCs, WBCs and platelets count in CIS intoxicated groups. Significant improvements in some of these parameters were reported with GB prior-treatment. Conclusion: Prior-treatment with GB partially attenuated the CIS induced anemia, leukocytopenia, thrombocytopenia and nephrotoxicity through its antioxidant and anti-apoptotic properties.
  Asmaa F. Khafaga and Aida E. Bayad
  This study was conducted to evaluate the possible protective effect of Ginkgo biloba (GB) against testicular damage and oxidative stress induced by acute or subchronic intoxication with cisplatin (CIS) in rats. Sixty male albino rats were classified into 6 equal groups (n = 10). Rats were treated orally with 150 mg kg b.wt. day G1 GB extract for 5 successive days before and 25 successive days after induction of toxicity by i.p. injection of CIS. Rats received CIS either acutely as a single injection of CIS (24 mg kg–1 b.wt.) or sub chronically with four equal doses of CIS (6 mg kg–1 b.wt.) once weekly. After 72 h from the last CIS injection, pathological and oxidative testicular toxicity as well as serum testosterone level and sperm indices were evaluated. Rats exposed to subchronic CIS treatment (alone or with prior GB co-treatment) displayed a significant decrease (p<0.05) in reproductive organs weight, caudal sperm count and motility, serum testosterone level and testicular GSH-PX and significant increase (p<0.05) in sperm abnormalities and testicular MDA. This reproductive toxicity was accompanied with necrotic and degenerated lesions in the seminiferous tubules. By contrast, in rats exposed to acute CIS treatment, prior treatment with GB partially ameliorated the subsequent harmful effects of CIS. In conclusion, pretreatment with GB mildly attenuated the reproductive damage induced by single CIS injection, while it failed to improve the damage induced by subchronic treatment.
 
 
 
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