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Articles by Asis Bala
Total Records ( 3 ) for Asis Bala
  Sudipta Das , Sanjib Bhattacharya , Biswakanth Kar , Goutam Pramanik , Pallab K Haldar and Asis Bala
  Background: Diospyros cordifolia Roxb. (Ebenaceae), commonly known as Indian ebony is used traditionally for several medicinal purposes. The present study was designed to investigate the anticonvulsant and sleep potentiation effect of methanolic extract of Diospyros cordifolia stem bark (MEDC) in Swiss albino mice. Results: The anticonvulsant effect of the MEDC at the doses of 25, 50 mg kg-1 body weight (b.wt.), intraperitoneally (i.p.), was examined against pentylenetetrazole (PTZ, 80 mg kg-1 b.wt; i.p.) and strychnine (STR, 2.5 mg kg-1 b.wt; i.p.) induced convulsions in mice. MEDC (50 mg kg-1 b.wt; i.p.) significantly delayed (p<0.01) the onset and antagonized PTZ and STR induced seizures. Diazepam (2 mg kg-1 b.wt; i.p.) was used as reference drug for anticonvulsant assessment. Further the study was undertaken to evaluate the pentobarbitone induced sleep potentiation effect of MEDC (25 and 50 mg kg-1 b.wt; i.p.) in mice and the extract significantly increased pentobarbitone (45 mg kg-1 b.wt; i.p.) induced sleeping time in a dose dependent manner. Conclusion: Therefore, the present study demonstrated that D. cordifolia bark possessed remarkable anticonvulsant efficacy demonstrating depressant action on the central nervous system.
  Siva Prasad Panda , Nilanjan Sarkar , Sudipta Das , Asis Bala and Pallab Kanti Haldar
  Objective: The objective of the present study was to evaluate the possible analgesic and anti-inflammatory activity of the root of Cucumis callosus (Rottl.) Cogn. (Cucurbitaceae) using different animal models. Materials and Methods: The methanol extract of the identified root part of plant Cucumis callosus was used for the evaluation of antinociceptve effect using three animal models namely; acetic acid-induced writhing response, hot plate method and the tail flick test in mice. The anti-inflammatory activity was established using carrageenan, dextran and histamine induced rat acute paw oedema models. However cotton pellet induced granuloma model in rats was used to establish its effect in the chronic model of inflammation. Results: In the study the methanol extract of Cucumis callosus (MECC) exhibited significant (p<0.01) analgesic effect at a dose of 200 and 400 mg kg–1 b.wt., p.o. in mice in all the models. The MECC also exhibited significant (p<0.01) anti-inflammatory activity in all the models used for acute inflammation. The MECC at 400 mg kg–1 inhibited 25.0% of granuloma formation, whereas indomethacin at of 10 mg kg–1 showed 47.7% inhibition in cotton pellet induced granuloma model (p<0.01). However, the extract and indomethacin were effectively preventing the transudation of the fluid. Conclusion: Thus, the present study revealed that the methanol extract of the root of Cucumis callosus exhibited significant analgesic and anti-inflammatory activity that will light a new study weapon for ethnopharmacological study in future.
  Purbajit Chetia , Asis Bala , Bidita Khandelwal and Pallab Kanti Haldar
  Background: β-carotene and naringenin are two plant derived molecules which posses antioxidant property. Naringenin is the predominant flavanone found in grape fruit. β-carotene is a natural fat-soluble pigment found principally in plants. Beta-carotene is converted by the body into vitamin A and acts a powerful antioxidant and helps support the immune system. Objective: Present studies were performed to compare the free radical scavenging property of β-carotene and naringenin with respect to vitamin C and N-acetyl cysteine which are the synthetic compounds and posses the potent antioxidant property. Materials and Methods: Various biochemical assay like DPPH, hydroxyl radical, nitric oxide and superoxide scavenging activity test were carried out by considering different concentration of the compounds. Results: It was found that β-carotene and naringenin showed a remarkable capacity to scavenge all the tested reactive species in a dose dependent manner and all the IC50 values (Mean±SEM) for three individual experiments being found at the μg mL-1 level (66±2.34-84.99±2.84 μg mL-1) which was comparable to synthetic compound vitamin C and N-acetyl cysteine. vitamin C and N-acetyl cysteine was a well established synthetic antioxidant used in different inflammatory disorder however, the prohibitive synthesis cost of these drugs coupled with the need for long-term therapy results in a high frequency of side-effects, making it imperative for better and safer drugs to be made available. So we are hopeful that naturally occurring antioxidant can also be a replacement for treatment of free radical mediated inflammatory diseases.
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