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Articles by Asim Kart
Total Records ( 5 ) for Asim Kart
  Asim Kart , Mehmet Elmali , Kursat Yapar and Hilmi Yaman
  Anabolic agents are used to increase live body weight in food animals. Zeranol is such an agent applied to cattle as subcutaneous implants in some countries. There is the potential risks that zeranol could affect hormonal and mineral metabolisms and have carcinogenic and teratogenic effects. Due to potential risks on animal and public health, use of zeranol as an anabolic agent was banned in Europian Union and in Turkey. In this study, it was aimed to investigate the presence of zeranol in ground beef samples marketed in Kars city which is one of the important ports in food animal production in Turkey. Seventy ground beef samples were collected from the retail shops to monitor occurrence of zeranol. The quantitative analysis of zeranol in beef samples were carried out by Competitive Enzyme Immune Assay (ELISA) test procedure as described by R-Biofarm GmBH, Germany ((Ridascreen® Zeranol, Tissue Samples, muscle, liver, kidney etc. Art. No: R3301). Of the 70 ground beef samples analyzed, 66 samples (94.28%) had level of zeranol under the detection limit (62 ppt), while 4 samples out of 70 (5.72%) contained zeranol ranging from 100-110 ppt.
  Mehmet Elmali , Kursat Yapar , Asim Kart and Hilmi Yaman
  Aflatoxins are secondary metabolites produced by certain strains of Aspergillus species. They have immunsupresive, genotoxic, hepatoxic and carcinogenic (particularl liver cancer) effects which are the common problems worldwide for people of all age groups. This study was aimed to investigate the presence and levels of AFM1 in the milk powder sold in retail stores of Kars, Erzurum, Mersin, Konya and Ankara vicinities in Turkey. AFM1 was determined in 62.5% of all samples analyzed. Amount of the AFM1 in samples was higher in 45% of the samples than the maximum allowed level according to the Turkish Food Codex (TFC) criteria (500 ng kg 1). Consequently, milk powders sold in retail stores in Turkey pose a great risk for public health. Serious programmes controlling the occurence of the aflatoxin will surely help on dealing with the risk factors.
  Asim Kart and Ali Bilgili
  Ionophores are antibiotics which are used as coccidiostat and growth promotant in veterinary practice. The ionophores make complexes with mono and divalent cations and facilitate the movement of metal ions by providing lipophilic channels thourough the hyrophobic lipid membranes. Use of ionophores are generally known to be safe and effective at the therapeutic doses in animal species. The most commonly used ionophores monensin, lasalocid and salinomicin are incorporated in the feed to prevent cocsidiosis and increase feed efficiency in poultry and cattle, respectively. However, accidental overdose, misuse, mixing errors and accidental ingestion in non-target species could result in toxicity in a number of animals. Horses, cattle, avian species, dogs, cats and rats are sensitive to ionophore toxicity. Toxic effects of ionophores are thought to be mediated by disrupting the normal ionic gradients of cells leading to mitochondrial damage, lack of cellular energy. A well-known toxic effect of ionophores is cardiac toxicity and muscle degeneration in suspected species. However, one less commonly known effect of ionophores is associated with nervous system leading to the neuropathy which is manifested with myelin degeneration and ataxia. The general toxic aspects, mechanism of toxicity as well as neurotoxic effect of ionophores are reviewed in this study.
  Asim Kart , Stanley Leon Vanhooser and Subbiah Sangiah
  Lasalocid toxicity was associated with several neurotoxicity cases in animal species. Incidence of lasalocid neurotoxiciy shows a higher rate in chickens during heat stress with increased water salinity. In the present study, It studied the effect of lasalocid with or without 0.9 % NaCl in male Sprague Dawley. The rats were given 0, 10, 20, 40 mgkgG of lasalocid two times a day for 3 days with or without 0.9 % saline in the 1 drinking water. Rats showed ataxia in the 20 and 40 mgkgG dose groups with higher death rate in group 1 receiving 40 mgkgG of lasalocid. Dietary salt did not affect ataxia induced by lasalocid. While the optimum dose 1 to produce ataxia (without high mortality) appears to be 20 mgkgG of lasalocid, increasing salinity of water has 1 no effect on the neurotoxicity of lasalocid.
  Asim Kart
  Organophosphates (OPs) are known to produce a delayed neuropathy in man and domestic animals. Other than acute cholinergic toxicity of OPs, they have been known to cause a delayed neuropathy called Organophosphorus Induced Delayed Neuropathy (OPIDN). Clinical manifestation of OPIDN is characterized by a delay period which is observed between 8 to 14 days after dosing. Toxic signs induce flaccid paralysis of lower and upper limbs and changes in neurons defined as a central-peripheral distal sensory-motor axonopathy. Although the mechanism is not clearly understood, OPs toxicity is attributed to inhibition of NTE. The initiation of OPIDN requires inhibition of NTE. Methods to elucidate mechanism of the toxicity may include use of other chemicals which can potentiate or prevent toxicity. Phenylmethylsulfonyl Fluoride (PMSF) is one such agent which has been widely utilized in mechanistic studies of OPIDN. Phenylmethylsulfonyl fluoride is a serine protease inhibitor which has been used to elucidate the mechanism of OP induced delayed neuropathy. Phenylmethylsulfonyl fluoride prevents OPIDN when given prior to an OP compound, but if PMSF is administered after an OP compound it potentiates the neurotoxicity.
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