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Articles by Ashish Chauhan
Total Records ( 3 ) for Ashish Chauhan
  Ashish Chauhan and Balbir Kaith
  Utilizing the renewable waste biomass to procure advanced materials has been the aim of research. Various reaction parameters were optimized for the graft co-polymerization of Hibiscus sabdariffa cellulose fiber using binary vinyl monomeric mixture. The graft co-polymers thus obtained were characterized by XRD technique and the results received the supporting evidence by various other advanced analytical techniques. The percentage crystallinity and crystallinity index were found to decrease with increase in grafting while a reduction in moisture absorption was observed. There was an increase in physico-chemico-thermal resistance in the graft copolymers. These graft copolymer can be used in various scientific applications.
  Baljinder Kaur , Praveen Balgir , Bharti Mittu , Ashish Chauhan and Balvir Kumar
  Anti-Gardnerella vaginalis, Lactobacillus fermentum bacteriocin HV6b producing strain was isolated from vaginal swabs of healthy, fecund females. It was identified, purified and further characterized physicochemically. The relative molecular mass of bacteriocin was found to be less than 7 kDa. Maximum bacteriocin production was observed at 37°C, pH 6.5 after 16-18 h of incubation Proteinase K and pepsin strongly inhibited bacteriocin production. The bacteriocin has purified by absorption desorption method and characterized by reverse phase liquid chromatography. It exhibited high thermal stability and showed inhibitory activity over wide range of pH. The study revealed the possibility of using bacteriocin for bio-medical use and the L. fermentum strain as probiotic.
  Neha Chandel , Ashish Chauhan and Kamlesh Guleria
  The tumor suppressor gene TP53 rs1800371 polymorphism (g.11370 C>T, c.139C>T, p.Pro47Ser) has been extensively investigated as a potential risk factor for different types of cancers and many diseases, but the results have been inconclusive. After searching multiple electronic databases to investigate the association between the p.Pro47Ser polymorphism and disease susceptibility, the present study has identified eleven eligible case-control studies, after investigating 2,502 cases and 3,740 controls. Also, four case-studies were included, investigating 225 cases. The genotypic frequency of Pro/Pro genotype in all the case-control studies was 100% (approximately). That led to conclude that there is no association between TP53 rs1800371 polymorphism and disease susceptibility. Published results seem to be driven by technical artifacts rather than justified biological effects. In order to determine the potential clinical implications of this polymorphism, future genetic association studies should use more rigorous genotyping methods and avoid the use of tumor tissue as a source of DNA to prevent genotype misclassification due to loss of heterozygosity.
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