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Articles by Aseer Manilal
Total Records ( 5 ) for Aseer Manilal
  A. Idhayadhulla , R. Surendra Kumar , A. Jamal Abdul Nasser and Aseer Manilal
  New pyrrole derivatives (2,3) were synthesized by condensation method and synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis. The novel pyrrole derivatives were screened for anticoagulant activity against Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT) coagulation assays and compound (3) is highly response for anticoagulant activity compared with compounds (1) and (2) and standard Heparin at concentration (60 μg mL-1) against APTT assay. The compound 3 showed highly significant anticoagulant effect and could be considered as leads for further investigations.
  Sujith Sugathan , Aseer Manilal , Joseph Selvin , Akbar Idhayadhulla , Radhakrishnan Surendra Kumar and M.V.N. Panikkar
  Seaweed-associated marine bacteria were recognized as a potential source of antimicrobial compounds. In the present study, a total of 27 epiphytic bacteria were isolated from four species of seaweeds collected from the Kollam coast (Indian Ocean) were investigated for antagonistic activity by cross streak method. Of the 27 bacterial isolates, 4 strains inhibited the growth of at least one shrimp vibrio pathogen tested. The active strains were further subjected to agar well diffusion assay. The result indicates that among the four seaweed isolates, SWI-24 strain exhibited highest spectrum of activity against all the tested shrimp pathogens. The molecular characterization based on partial 16S rRNA sequence revealed that the active isolate SWI-24 was Pseudoalteromonas sp. The efficient antagonistic potential exhibited by the SWI-24 against pathogenic shrimp bacteria may further reflect the potential use of seaweed-associated bacteria in managing the shrimp/fish disease.
  Akbar Idhayadhulla , Radhakrishnan Surendra Kumar , Abdul Jamal Abdul Nasser and Aseer Manilal
  The compounds of 2,2'-[(3,5-dimethyl-1H-pyrrole-2,4-diyl) dicarbonyl]dihydrazine carboxamide(2), 2,2’-[(3,5-dimethyl-1H-pyrrole-2,4-diyl)dicarbonyl]dihydrazine carbothioamide(3), 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazine carboxamide(5) and 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine -3,5-diyl]dicarbonyl}dihydrazine carbothioamide (6) were synthesized from hydrazinolysis method and synthesized compounds were confirmed by IR, 1H-NMR, 13C-NMR, mass spectral, mass spectral fragmentation and elemental analysis. Synthesized compounds were screened for antimicrobial and anticancer activities. Evaluation of antibacterial, antifungal activity showed that the compounds exhibited better results than reference drugs. The newly synthesized compounds have been screened for preliminary anticancer activity against HepG2(Liver), Hela(Cervical), MCF-7(Breast) cancer cells. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
  Aseer Manilal , Nooruddin Thajuddin , Joseph Selvin , Akbar Idhayadhulla , Radhakrishnan Surendra Kumar and Sugathan Sujith
  A total of twenty marine algae were collected from the rocky intertidal and subtidal regions of the southwest coast of India and extracted in methanol. The extracts were evaluated for larvicidal activity against the second and third instar larvae of the human vector mosquito Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). Analysis on the activity profile of the above marine algae indicated that the early stage larvae were very sensitive to seven seaweed extracts that had been tested. Among the seven marine algae, Lobophora variegata was highly potential, showing LD50 value of 70.38 and 79.43 μg mL-1 on the 2nd instar larvae of A. aegypti and C. quinquefasciatus respectively. The rank of larvicidal potency in highly active algae in the descending order is as follows: Lobophora variegata (Dictyotaceae)>Spatoglossum asperum (Dictyotaceae)>Stoechospermum marginatum (Dictyotaceae)>Sargassum wightii (Sargassaceae) >Acrosiphonia orientalis (Acrosiphoniaceae)>Centroceras clavulatum (Ceramiacea)>Padina tetrastromatica (Dictyotaceae). This is the first report that envisaged the mosquito larvicidal efficacy of L. variegata from the Indian coast. Therefore, this marine alga could be recognized as a potential resource of natural insecticide and can be developed to replace synthetic insecticides in future.
  R. Surendra Kumar , Aseer Manilal , A. Jamal Abdul Nasser , Behailu Merdekios , Xiangxiong Chen and A. Idhayadhulla
  Novel diverse 1, 4-dihydropyridine analogues were prepared from cyclization method. Synthesized compounds were characterized from IR, 1H-NMR, 13C-NMR, mass spectral, elemental analysis and mass spectral fragmentation method. The reaction was performed using ordinary condensation type, which enabled to easy work-up and good yield. Synthesized compounds (1-4) were screened for antimicrobial activity. Among these compounds (4) (MIC:8 μg mL-1) has highly antibacterial activity against E. coli compared with standard Ciprofloxacin and compound (4) (MIC: 4 μg mL-1) has highly antifungal active against C. albicans compared with Clotrimazole.The synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound (4) is highly active against HepG2, MCF-7 and Hela (Cervical) and these have been selected for advanced preclinical development. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
 
 
 
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