Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Arumugam Gopalakrishnan
Total Records ( 2 ) for Arumugam Gopalakrishnan
  Mani Saminathan , Ram Bahal Rai , Kuldeep Dhama , Babu Lal Jangir , Subramaniyam Suresh , Gopikunte Jayaramaiah Ranganath , Inbaraj Sophia , Kuppusamy Karuppanasamy , Singaram Barathiraja and Arumugam Gopalakrishnan
  N-Methyl-N-Nitrosourea (NMU) is a highly specific mammary gland carcinogen that act directly and does not require metabolic activation. The novel medicinal plant Morinda citrifolia, also called as Noni, has broad therapeutic effects such as antibacterial, antiviral, antifungal, anticancer, analgesic, anti-inflammatory, anti-oxidant and immune enhancing effects. The present study was conducted to assess the beneficial effects of M. citrifolia fruit juice on antioxidant, hematological and biochemical alterations caused by NMU induced mammary carcinogenesis in Sprague-Dawley rats. The rats were divided into five groups viz., vehicle control group-A (n = 8), M. citrifolia control group-B (n = 8), NMU control group C (n = 15), M. citrifolia prevention group-D (n = 15) and M. citrifolia treatment group-E (n = 15). By the end of the 28 weeks experimental period all the animals were euthanized, blood was collected by heart puncture. M. citrifolia treatment significantly (p<0.05) increased the anti-oxidant enzymes such as catalase, superoxide dismutase and significantly (p<0.05) decreased the lipid peroxidation activity when compared to NMU control group-C. M. citrifolia exhibited a preventive effect against anaemia, lymphocytosis and neutrophilia in group-D and group-E when compared to group-C. Biochemical analyses showed normal levels of enzymes of liver and kidney in M. citrifolia treated groups- B, D and E rats, whereas NMU control group-C showed significant (p<0.05) decrease in albumin and total protein levels. These findings indicate that M. citrifolia fruit juice did not show any hepatotoxic or nephrotoxic effects. It was concluded that the M. citrifolia fruit juice ameliorates the adverse effects of NMU carcinogenesis and could be useful to treat mammary tumours in humans and animals.
  Mohd Iqbal Yatoo , Archana Saxena , Arumugam Gopalakrishnan , Mahmoud Alagawany and Kuldeep Dhama
  Diabetes is a chronic endocrine disease with global prevalence and rising incidence. Diabetes represents a major health issue in all age groups in the present times owing to its multisystem involvement and serious complications. Despite drug development and therapeutic interventions, successful treatment of diabetes still remains a challenge and worldwide research is focused on these aspects. Conventional antidiabetic medicines include injectable insulins, sulfonylureas, biguanides, glucosidase inhibitors and glinides. New class include inhalable insulins, incretin mimetics, amylin analogues, gastric inhibitory polypeptide analogues, peroxisome proliferator activated receptors and dipeptidyl peptidase-4 inhibitors. From effectiveness of synthetic drugs, chemicals or hormones to issues of cost, availability and side effects, novelty in preparations to methods of administration, all fields are explored for better management of the disease. Medicinal plants with antidiabetic potential have been recent areas of research. Asteraceae, Araliaceae, Cucurbitaceae, Lamiaceae, Leguminoseae, Liliaceae, Moraceae and Rosaceae are the major antidiabetic plant families. The most active plants are Allium sativum, Gymnema sylvestre, Citrullus colocynthis, Trigonella foenum greacum, Momordica charantia and Ficus bengalensis. Their phytoconstituents have shown promising results in diabetes management; but need to be properly evaluated at molecular, physiological, pharmacological and toxicological levels for various prophylactic and therapeutic attributes, mechanisms of action, efficacy and safety before application in diabetes. The common phytoconstituents include polyphenols, flavonoids, terpenoids, tannins, alkaloids, saponins etc. Exploration of novel targets like glucagon-like peptide-1 (GLP-1), sodium-glucose co-transporter 2 (SGLT-2) and dipeptidyl peptidase 4 (DPP-4) for antidiabetic drugs and medicinal plants with emphasis on site specific effectiveness and overcoming problems of resistance, side effects, prolonged usage and high cost, are being investigated for future research.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility