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Articles by Arnaud Ngongang Djintchui
Total Records ( 1 ) for Arnaud Ngongang Djintchui
  Jean-de-Dieu Tamokou , Joseph Tsemeugne , Emmanuel Sopbue Fondjo , Prodipta Sarkar , Jules-Roger Kuiate , Arnaud Ngongang Djintchui , Beibam Luc Sondengam and Prasanta Kumar Bag
  Objective: The emergence of resistance to the major classes of antibacterial drugs is recognized as a serious health concern. Chemotherapy of cervical cancer, a devastating cancer with increasing worldwide incidence and mortality rates is largely ineffective. The discovery and development of effective antibacterial/anticancer agents is urgently needed. The present study reports on the evaluation of antibacterial and anticancer properties of some azo compounds containing thiophene backbone. Methodology: The antibacterial activity of the synthesized compounds was assessed by performing Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and the time-kill kinetic study, while the cytotoxic activity was determined by the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay using HeLa (cancer cell lines) and Vero (normal) cells. Results: All of the compounds tested here showed significant antibacterial activity against the strains of Gram-positive bacteria, Staphylococcus aureus and Gram-negative multi-drug resistance bacteria, Vibrio cholerae (causative agent of cholera) and Shigella flexneri (causative agent of shigellosis), as well as the significant cytotoxic activity (LC50, 1.03-106.73 μg mL–1) against HeLa cells. Among these, compounds 3, 6 and 7 showed the most antibacterial (MIC, 8-64 μg mL–1) and cytotoxic (LC50, 1.03-2.37 μg mL–1) activities with selectivity index values ranged from 71.19-144.80, which were much higher than that of the reference drug, paclitaxol. The presence of the nitro functional group in compounds 3 and 6 could explain their good antibacterial and cytotoxic activities. Conclusion: These results indicate that the synthesized compounds have both antibacterial and anticancer properties with no toxicity to normal cells.
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