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Articles by Arif S.W. Kusuma
Total Records ( 2 ) for Arif S.W. Kusuma
  Keri Lestari , Haig Babikian , Yusef Babikyan , Imam Megantara , Rajeev Kumar Jha , Arif S.W. Kusuma , Margaretha Prayudhi Novantiana and Fransiskus Xaverius Sudirman
  Background and Objective: Avian Infectious Bronchitis Virus (AIBV) is a highly infectious pathogen of chicken. There is no medication and vaccine developed yet due to its highly mutable nature. The objective was to formulate a blend that can be effective against the viral infection in chicken. Material and Methods: Several natural essential oils, like, Gardenia jasminoides, Commiphora myrrha, Boswellia serrata, Foeniculum vulgare and Daucus carota with anti-viral properties were blended and tested against Avian Infectious Bronchitis Virus H120 (AIBV H120) strain using in vitro medium. The trial was conducted in an allantoic fluid medium. Different concentration of NOB was inoculated into the allantoic-fluid to challenge with the lethal dose of virus. Results: The Natural Oil Blend (NOB), at its minimum concentration up to 0.01 mL of 0.1%, was effective against the AIBV H120 strain. The NBO concentration lower than 0.1% was not sufficient to deactivate the AIBV H120 strain. The embryos up to 0.1% of NBO treated groups and negative control embryos were alive and tested negative to AIBV H120 strain, whereas the embryos in positive control died and tested positive. Conclusion: The in vitro trial proven that the essential oil Blend can deactivate the Avian Infectious Bronchitis Virus H120 (AIBV H120) in in vitro medium.
  Hanny Nugrahani , Arif S.W. Kusuma , Jutti Levita and Rizky Abdulah
  Background and Objective: Selenium has been reported to improve the anticancer activity of broccoli sprouts and florets. However, the anticancer properties of the combination of selenium and sulforaphane, the active anticancer compound in Broccoli have not been well investigated. This study was conducted to investigate the role of the combination of selenium and sulforaphane in inhibiting the proliferation of MCF-7 cells. Materials and Methods: Methylseleninic acid was used in this study as it can directly convert to monomethylated selenium for exhibiting its anticancer activity. The anti-proliferative properties of both sulforaphane and methylseleninic acid were analyzed separately and in combination with MCF-7 cells using WST assays. The combinations of sulforaphane and methylseleninic acid in ratios of 1:2 and 1:3 were analyzed using the Chou-Talalay method. Results: The 24 h IC50 values of sulforaphane and methylseleninic acid alone against MCF-7 cells were 24.55 and 182.35 μM, respectively. Furthermore, the results of the Chou-Talalay equation suggested that the combinations of sulforaphane and methylseleninic acid in ratios of 1:2 and 1:3 showed combination index values <1 at all tested concentrations. Conclusion: This study suggested that the combinations of sulforaphane and methylseleninic acid exert synergistic antiproliferative properties against the MCF-7 breast cancer cell line.
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