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| Articles
by
Archana Saxena |
Total Records (
2 ) for
Archana Saxena |
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Mohd. Iqbal Yatoo
,
Umesh Dimri
,
Arumugam Gopalakrishan
,
Mani Saminathan
,
Kuldeep Dhama
,
Karikalan Mathesh
,
Archana Saxena
,
Devi Gopinath
and
Shahid Husain
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This study demonstrated the antidiabetic and antioxidant potential of Pedicularis longiflora Rudolph, a Himalayan wild herb, in alloxan
induced diabetic rats. Seven groups of wistar rats (n = 6) were divided into healthy control (I) and diabetic control (II) groups, both without
any treatment, test groups (III, IV and V) treated with varying concentration of ethanolic extract of Pedicularis longiflora and standard
groups treated with N-acetyl cysteine as standard antioxidant (VI) and glibenclamide as standard antidiabetic drug (VII). Diabetic
biomarkers and oxidative stress indices were evaluated on day 0, 7 and 14 of treatment. Glucose, glycated haemoglobin (GHb) and
fructosamine showed a decrease of 23.08, 33.85 and 43.46%, respectively in group IV than group III (15.06, 46.13 and 23.95%) and group
V (15.99, 27.77 and 24.84%) whereas, insulin showed significant (p<0.05) increase in group IV (15.43%) and group V (5.12%), but not than
group III (16.82%) on day 14 of treatment. Concentration of reduced glutathione (GSH) and activity of superoxide dismutase (SOD) was
increased (p<0.05) whereas, levels of lipid peroxide (LPO) and Nitric Oxide (NO) were decreased (p<0.05) in test groups on day 14 of
treatment compared to diabetic control group. Liver homogenate showed lower levels (p<0.05) of LPO and NO, whereas, pancreatic
homogenate showed higher levels (p<0.05) of GSH and lower levels (p<0.05) of LPO in test groups. These findings can be attributed to
antidiabetic and antioxidant potential of P. longiflora Rudolph, however, group IV (500 mg kg–1 b.wt.) showing better response indicating
its safe use as natural medicine. |
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Mohd Iqbal Yatoo
,
Archana Saxena
,
Arumugam Gopalakrishnan
,
Mahmoud Alagawany
and
Kuldeep Dhama
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Diabetes is a chronic endocrine disease with global prevalence and rising incidence. Diabetes represents a major health issue in all age groups in the present times owing to its multisystem involvement and serious complications. Despite drug development and therapeutic interventions, successful treatment of diabetes still remains a challenge and worldwide research is focused on these aspects. Conventional antidiabetic medicines include injectable insulins, sulfonylureas, biguanides, glucosidase inhibitors and glinides. New class include inhalable insulins, incretin mimetics, amylin analogues, gastric inhibitory polypeptide analogues, peroxisome proliferator activated receptors and dipeptidyl peptidase-4 inhibitors. From effectiveness of synthetic drugs, chemicals or hormones to issues of cost, availability and side effects, novelty in preparations to methods of administration, all fields are explored for better management of the disease. Medicinal plants with antidiabetic potential have been recent areas of research. Asteraceae, Araliaceae, Cucurbitaceae, Lamiaceae, Leguminoseae, Liliaceae, Moraceae and Rosaceae are the major antidiabetic plant families. The most active plants are Allium sativum, Gymnema sylvestre, Citrullus colocynthis, Trigonella foenum greacum, Momordica charantia and Ficus bengalensis. Their phytoconstituents have shown promising results in diabetes management; but need to be properly evaluated at molecular, physiological, pharmacological and toxicological levels for various prophylactic and therapeutic attributes, mechanisms of action, efficacy and safety before application in diabetes. The common phytoconstituents include polyphenols, flavonoids, terpenoids, tannins, alkaloids, saponins etc. Exploration of novel targets like glucagon-like peptide-1 (GLP-1), sodium-glucose co-transporter 2 (SGLT-2) and dipeptidyl peptidase 4 (DPP-4) for antidiabetic drugs and medicinal plants with emphasis on site specific effectiveness and overcoming problems of resistance, side effects, prolonged usage and high cost, are being investigated for future research. |
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