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Articles by Anwarul Islam
Total Records ( 8 ) for Anwarul Islam
  Badrul Alam , Sarowar Hossain , Razibul Habib , Julia Rea and Anwarul Islam
  Methanolic extract of Lannea coromandelica Linn. bark (MLCB) was subjected to evaluate its antioxidant and analgesic properties. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate as well as tail immersion method and acetic acid-induced writhing test with formalin induced pain in mice, respectively. To evaluate antioxidant potential of MLCB, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical as well as total Reactive Oxygen Species (ROS) and assessment of reducing power were used. The extract, at the dose of 200 and 400 mg kg-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods whereas significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. In DPPH and total ROS scavenging method, MLCB showed good antioxidant potentiality with the IC50 value of 12.32±0.16 and 34.72±0.48 μg mL-1, respectively with a good reducing power. In conclusion this study demonstrated the strong antioxidant and antinociceptive activities of methanolic extract of the bark of L. coromandelica. Altogether, these results suggest that the MLCB could be used as a potential antinociceptive agent along with its antioxidant potentiality.
  Anwarul Islam , Abu Sayeed , Md. Anwar-Ul Islam , G. R. M. Astaq Mohal Khan , M. Helal U. Biswas and M. Shah Alam Bhuiyan
  The research work was conducted to investigate the antimicrobial and cytotoxic evaluation of a flavonone. The flavonone, 5-methoxy-7-hydroxy flavonone (1), has been isolated from the leaves extract of Zanthoxylum budrunga and its structure was established on the basis of structural evidence. This is the first report of its occurrence from the plant. The compound (1) showed significant antimicrobial activity against a number of pathogenic bacteria and fungi. The minimum inhibitory concentration (MIC) of the compound (1) was found to be 16μg ml‾1 against Staphylococcus aureus. The compound showed prominent cytotoxic activity the LC50 and LC90 values of the compound (1) were found to be 16.24 and 56.56μg ml‾1, respectively.
  Anwarul Islam , Abu Sayeed , Golam Sadik , M. Motiur Rahman and G. R. M. Astaq Mohal Khan
  Two clerodane diterpines viz., Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14) E-diene-15-oic acid (2) were isolated from the petroleum ether (C2H5-O-C2H5) extract of the seed of Polyalthia longifolia and were screened against fourteen pathogenic bacteria for their antibacterial activities. The test materials exhibited strong activities against most of the test bacteria. The minimum inhibitory concentration (MIC) of the compound (1) and (2) was determined against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella flexneriae and Shigella boydii which were 64, 64, 32, 16 and 32μg ml-1 for compound (1) and 16, 32, 8, 4 and 16 μg ml-1 for compound (2), respectively. The cytotoxic activity of the compound (1) and (2) was determined by brine shrimp lethality bioassay. Both the compounds showed significant cytotoxic activities and LC50 values of Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14)E-diene-15-oic acid (2) were 3.16 and 2.52μg ml-1, respectively.
  A.K.M. Nasimul Islam , M. Abbas Ali , Abu Sayeed , Anwarul Islam , S.M. Kousik Arefin , Naznin Ara Khatune and G.R.M. Astaq Mohal Khan
  Barks of Caesalpinia pulcherrima yielded a glycoside, Lathyrol-3-phenylacetate-5,15-diacetate (CP-2). The compound, CP-2, showed significant antibacterial and antifungal effects. The minimum inhibitory concentration (MIC) of CP-2 against Bacillus cereus and Shigella dysenteriae was determined and the values were 64 and 32 μg ml-1, respectively. The cytotoxicity of CP-2 was determined by brine shrimp lethality bioassay and LC50 value was 5.39 μg ml-1. The mortality rate by the compound with highest concentration suggests the drug to be used at highest doses and also suitable for further clinical trial.
  M. Badrul Alam , M. Sarowar Hossain , Nargis Sultana Chowdhury , M. Ehsanul Haque Mazumder , M. Ekramul Haque and Anwarul Islam
  In course of investigation on natural antioxidants, the present study was aimed to report the antioxidant activities, both in vitro and in vivo, of the crude methanolic extracts of the whole plant of Oxalis corniculata Linn along with its various organic fractions. The different assay methods, including total antioxidant activity, scavenging free radical, authentic peroxynitrite, nitric oxide and reducing power assessment were used to evaluate the antioxidant potential of the crude extract and its organic fractions. The ethylacetate (EtOAc) fraction, showed strong activity in all the model systems tested and in peroxynitrite model this fraction (IC50 value of 2.29±0.18 μg mL-1) exerted three-fold stronger activity than standard penicillamine (IC50 value of 6.20±0.32 μg mL-1). The reducing power of the extract was found to be concentration dependent. The administration of the extract/fractions at a dose of 250 and 500 mg kg-1 body weight to the male Wistar rats increased the percentage inhibition of reduced glutathione, superoxide dismutase and catalase significantly. Whereas, lipid peroxidation level in hepatotoxic rats markedly decreased at a dose of 500 mg kg-1 body weight after 7 days. The total phenol and flavonoid content were also measured in the crude extract along with its organic fractions. The Brine shrimp lethality bioassay was used to determine the toxicity of the extracts and Vincristin sulphate was used as positive control. The dichloromethane (CH2Cl2) fraction showed highest activity (LC50 value of 29.02±1.16 μg mL-1) and other showed activity in the order of: EtOAc fraction >n-BuOH fraction> MeOH extract > aqueous fraction. Taken together, these results suggest that O. corniculata extract has strong antioxidant properties and further validate the traditional use of this plant.
  M. Badrul Alam , M. Sarowar Hossain , N. Sultana Chowdhury , M. Asadujjaman , Ronok Zahan , M. Monirul Islam , M. Ehsanul Haque Mazumder , M. Ekramul Haque and Anwarul Islam
  The present study was designed to investigate the antioxidant, anti-inflammatory and antipyretic potential of the methanolic extract along with its organic soluble fractions of the fruits of Trichosanthes dioica Roxb. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl) and NO (nitric oxide) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.32±0.16 and 5.38±0.07 μg mL-1 for DPPH and NO assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their anti-inflammatory (carrageenan induced paw edema in rats) and antipyretic (Brewer’s yeast induced pyrexia) activities at a dose level of 100, 200 and 400 mg kg-1 body weight for MeOH extract. Methanolic extract showed a dose dependent and significant (p<0.005, p<0.05) anti-inflammatory and antipyretic effect. Dichloromethane fraction (CH2Cl2) and Ethyl acetate fractions exhibited similar activity using a dose of 200 mg kg-1 b.wt. in these models. The pharmacological activities of the (CH2Cl2) fraction were lesser than the MeOH extract and other fractions. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Altogether, these results suggest that the MeOH extract and its organic soluble fractions EtOAc could be used as a potential antioxidant, anti-inflammatory and antipyretic agent.
  Anwarul Islam , Abu Sayeed , M. Shah Alam Bhuiyan , M. Ashik Mosaddik G. , R. M. Astaq Mohal , M. A. Rashid and Md. Anwar-UI Islam
  Three terpenes lup-20 (29)-en-3-one (ZB-1), 11 , 13-dihydro-1epireynosin (ZB-2) and tetracyclic diterpenol-15-cinnamate (ZB-3) were isolated from the bark of the plant Zanthoxylum budrunga and were screened against some pathogenic bacteria and fungi. They were found significant in vitro antibacterial and antifungal. The zones of inhibition produced by the pure compounds were laid between 9 mm to 23 mm. The MIC values of the three isolated compounds were also determined against four test organisms (107 cells/ml) and were found to be effective between 16 μg/ml to 128 μg/ml.
  Farque Ahmed , Abu Sayeed , Anwarul Islam , S.M. Abdus Salam , Golam Sadik , M.A. Sattar and G.R.M. Astaq Mohal Khan
  The petroleum ether, ethyl acetate and methanol extracts of Vanda roxburghii as well as glycoside, melianin (VR-1) isolated from it were screened for antimicrobial activity against a wide variety of bacteria and fungi. The ethyl acetate and methanol extracts showed moderate antibacterial activity against almost all the tested organisms. The compound melianin (VR-1) exhibited strong activity against all the tested organisms and produced zone of inhibition between 17 and 27 mm. The petroleum ether extract was found comparatively less active against the organisms. All the tested materials showed antifungal activity against Aspergillus fumigatus, Candida albicans, Hensinela californica and Rhizopus arijae. The minimum inhibitory concentrations (MIC) of melianin against Bacillus cereus, Bacillus subtilis, Escherichia coli and Shigella dysenteriae were 32, 64, 64 & 128 μg ml–1 respectively. The findings may provide the basis for traditional use of this plant in the treatment of infectious diseases.
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