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Articles by Anwaar Ahmad
Total Records ( 4 ) for Anwaar Ahmad
  Anwaar Ahmad , Andria Rasile Robinson , Anette Duensing , Ellen van Drunen , H. Berna Beverloo , David B. Weisberg , Paul Hasty , Jan H. J. Hoeijmakers and Laura J. Niedernhofer
  ERCC1-XPF endonuclease is required for nucleotide excision repair (NER) of helix-distorting DNA lesions. However, mutations in ERCC1 or XPF in humans or mice cause a more severe phenotype than absence of NER, prompting a search for novel repair activities of the nuclease. In Saccharomyces cerevisiae, orthologs of ERCC1-XPF (Rad10-Rad1) participate in the repair of double-strand breaks (DSBs). Rad10-Rad1 contributes to two error-prone DSB repair pathways: microhomology-mediated end joining (a Ku86-independent mechanism) and single-strand annealing. To determine if ERCC1-XPF participates in DSB repair in mammals, mutant cells and mice were screened for sensitivity to gamma irradiation. ERCC1-XPF-deficient fibroblasts were hypersensitive to gamma irradiation, and γH2AX foci, a marker of DSBs, persisted in irradiated mutant cells, consistent with a defect in DSB repair. Mutant mice were also hypersensitive to irradiation, establishing an essential role for ERCC1-XPF in protecting against DSBs in vivo. Mice defective in both ERCC1-XPF and Ku86 were not viable. However, Ercc1–/– Ku86–/– fibroblasts were hypersensitive to gamma irradiation compared to single mutants and accumulated significantly greater chromosomal aberrations. Finally, in vitro repair of DSBs with 3` overhangs led to large deletions in the absence of ERCC1-XPF. These data support the conclusion that, as in yeast, ERCC1-XPF facilitates DSB repair via an end-joining mechanism that is Ku86 independent.
  Zakirullah , Zahoor A. Swati , Anwaar Ahmad and Raziuddin
  Drought tolerance potential of five F10 brassica lines derived from interspecific crosses involving three genotypes of B. napus, two of B. juncea and one of B. carinata was assessed under green house conditions during crop season 1992-93. Relative leaf water contents (RLWC) were significantly altered by the three levels of moisture stress at flowering stage but genotypic differences were significant at the pod formation stage only. Leaf water potential (LWP) decreased with increasing stress and increased with age from flowering to pod stage. Under stress conditions plants generally took longer to complete 100% flowering, however, maturity was not significantly delayed. Brassica juncea was the earliest in reaching maturity followed by B. carinata and B. napus, respectively, while lines showed little differences. Leaf area decreased significantly with moisture stress, Whereas genotypic differences were significant for pod length, number of pods/main stock and number of secondary branches and non-significant for number of seed/pod and grain yield/plant. The Lines AY and WY derived from crosses between Altex X Yellow Raya and Westar x Yellow Raya, respectively were proved to be stress tolerant.
  Anwaar Ahmad , Zahoor A. Swati , Zakirullah and Raziuddin
  Considerable variation among the lines were observed for total oil contents, oleic acid, linoleic acid, linolenic acid, erucic acid and glucosinolates. Maximum oil contents were recovered from WY and MG followed by a group of five lines with almost similar values (47%) and these could be a material of choice for transferring this potential into a desirable background. None of the lines exhibited desired level of erucic acid and glucosinolates. Present study successfully identified lines with improved oil content which could be advanced and utilized in future breeding programs for high oil content.
  Zahoor A. Swati , Anwaar Ahmad , Zakirullah and Raziuddin
  Morphological differences among the Brassica lines for all the characters were statistically significant. Among the lines, AY produced maximum yield and was closely followed by WL and AAR with lower but statistically similar trend. As expected these lines were also statistically higher in number of pods per main stalk, pod size and thousand grain weight. Present efforts were quite successful in determining the genetic potential of different lines for yield and its components and are recommended for further testing and if proved stable could be released as an improved variety(s).
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