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Articles by Annaian Shanmugam
Total Records ( 2 ) for Annaian Shanmugam
  Namasivayam Subhapradha , Pasiyappazham Ramasamy , Alagiri Srinivasan , Annaian Shanmugam and Vairamani Shanmugam
  In this study, the antimicrobial potential of chitosan and its water soluble derivatives from gladius of squid Sepioteuthis lessoniana against eleven human pathogens (gram +ve and gram -ve bacteria) was investigated. Chitosan was extracted from the gladius through demineralization, deproteinization and deacetylation. Chitosan was chemically modified by reacting with DMF-chlorosulfonic acid and orthophosphoric acid to yield water soluble derivatives such as sulfated chitosan and phosphorylated chitosan, respectively. The antibacterial activity was assessed by well diffusion technique. Different concentrations of chitosan and water soluble derivatives were analyzed by MIC techniques. The structure of chitosan, sulfated chitosan and phosphorylated chitosan was elucidated by FT-IR spectroscopy. Chitosan showed maximum inhibition of 14 mm against S. aureus and minimum inhibition of 8 mm against K. pnemoniae and V. cholerae. SCL showed maximum inhibition of 14 mm against V. cholerae and E. coli. PCL showed maximum inhibition of 13 mm against V. cholerae and S. pnemoniae. Chitosan and its derivatives possess potent antibacterial activity against several pathogens among the eleven pathogens tested and could be used as an alternative antibacterial agent.
  Annaian Shanmugam , Thangaraj Amalraj , Chendur Palpandi Gnanasekar Devanathan and Thangavel Balasubramanian
  The isolated heparin and heparin-like Glycosaminoglycans (GAGs) from the cuttlefish Euprymna berryi was studied for the antimicrobial activity. The bacterial strains such as (Bacillus subtilis, Pseudomonas aeruginosa, Escheriachia coli, Staphylococcus aureus, Shigella flexineri) and fungal strains such as Aspergillus fumigatus Fusarium sp., Cryptococcus neoformans, Microsporium sp. and Candida albicans present study. various concentration (25, 50, 75 and 100%) used in this study. The heparin and heparin-like (GAGs) crude and purified sample showed activity against all the pathogenic bacterial strains. Whereas the antifungal activity in crude and purified sample was no activity against Microsporium sp. Fusarium sp. (crude) and Microsporium sp. (purified) respectively in all the concentration. The other all the fungal strains having activity in all the concentration. The activity of heparin and heparin-like GAGs extract was found to be higher in 100% concentration than the other concentration. In general the increasing concentration showed increasing activity of the extract. The heparin and heparin-like extract showing good antimicrobial activity are under going further analysis to identify the active constituents.
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