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Articles by Anna K. Jager
Total Records ( 2 ) for Anna K. Jager
  Aladdin M. Naqishbandi , Knud Josefsen , Mikael Egebjerg Pedersen and Anna K. Jager
  Rheum ribes Linn (Polygonaceae) root is used traditionally to treat diabetes, hemorrhoids, ulcers, and diarrhea. Here, the hypoglycemic effect of R. ribes root extract in healthy mice was investigated. Fasted mice were given a single dose of 50mg/kg of three extracts of different polarity from R. ribes by gastric feeding and the blood glucose was measured 0, 1, 2, 4, and 24h later. The aqueous extract showed a significant hypoglycemic effect. In vitro, the aqueous extract stimulated insulin release from INS-1E cells at both stimulatory (20mM) and non-stimulatory (1mM) glucose concentrations, thus suggesting a mechanism for the in vivo effect. The hypoglycemic active fraction was found to contain anthraquinone glycosides of aloe emodin, emodin, physcion, and chrysophanol derivatives.
  Gjoshe Stefkov , Svetlana Kulevanova , Biljana Miova , Suzana Dinevska-Kjovkarovska , Per Molgaard , Anna K. Jager and Knud Josefsen
  Context: The main objective of the study was to investigate the biochemical mechanism of the antidiabetic activities of the dry extracts of Teucrium polium L. ssp. capitatum (L.) Arcangeli (Lamiaceae), from Republic of Macedonia, traditionally used to treat diabetes. Materials and methods: Aerial parts of the plant were extracted in alcohol and freeze- or spray-dried, analyzed by high performance liquid chromatography (HPLC) and examined for insulinotropic effect in INS-1E cells in vitro. Their effect on blood glucose, lipids and carbohydrate-related enzymes was tested in normo- and streptozotocin hyperglycemic rats. Results and discussion: HPLC analyses revealed several flavonoids: luteolin, apigenin, cirsiliol, diosmetin, cirsimaritin and cirsilineol as both free aglycons and glycosides. The extract and mixture of commercial flavonoids showed a distinct insulinotropic effect on INS-1E cells at 500 μg/ml. Intragastric (i.g.) administration of identical doses of the extract (125 mg/kg) in both normo- and hyperglycemic rats was more efficient in lowering the blood glucose than intraperitoneal injection (35% vs. 24% reduction) with highest effect (50% reduction) 8 h after administration. After 10 days of treatment, the magnitude of the effect was comparable to i.g. administration of 2.5 mg/kg of glibenclamide (38% reduction). No effect was seen on blood lipid profiles. In OGTT (oral glucose tolerance test), the extract lowered blood glucose levels by ~35%. The treatment reduced hepatic glycogen and tended to normalize the activity of gluconeogenic enzymes. Conclusion: The results demonstrate that examined plant extracts contain flavonoids with insulinotropic and antihyperglycemic effects.
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