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Articles by Angelo Leone
Total Records ( 3 ) for Angelo Leone
  Angelo Leone , Maria Laura Uzzo , Giovanni Francesco Spatola , Tomasz Konopka , Giuseppe Pizzo , Biagio Valentino , Francesco Carini , Aldo Gerbino and Maria Buscemi
  We have used 12 Epulis taken during surgical operation and as control, some normal gingival specimen. The aim was to clarify the relationship between the degree of inflammation and NO production in several cases of Epulis, exhibiting different degree of inflammatory process and verifying the presence of cells involved in NO production. From the immuhistochemical data in our possession we can conclude that NO is one of the factor which module the pathogenecity degree of Epulis.
  Angelo Leone , Elvira Farina-Lipari , Aldo Gerbino , Francesco Burruano , Silvia Tortorici and Maria Buscemi
  Prostaglandins (PG) are chemical mediators for most physiological and pathological responses, including cytoprotection of the gastric mucosa, blood coagulation, inflammation and pain (1, 2, 3). E2 Prostaglandins (PG2) play an important role in the pathogenesis of periodontal diseases, since PG2 determines vasodilatation and increased vascular permeability, oedema and erythema. Therefore, it is not surprising to find high levels of PG2 in inflamed gingival tissues. Indeed, in inflamed gingival tissue, PG2 levels of the Gingival Fluid (GCF) are known to be higher in periodontitis than in healthy gingiva. Moreover, in different parodontitis the high PG2 level of the GCF is related to periodontal ligament loss. The pathogenensis of the periodontitis can be due to the high PG2 activation of the Matrix Metal-Protease (MMP), which is synthesized by monocytes and fibroblasts. Consequently, destruction of connective tissue on a large scale takes place. The aim of this research is two-fold: To test the COX-2 expression in the human epulis and study its involvement in the PG2 synthesis and to find a alternative terapy to treat gingival diseases.
  Aldo Gerbino , Luana Lipari , Annamaria Mauro , Angelo Leone , Salvatore Provenzano and Maria Buscemi
  This study was aimed to explain the functional role of the mediation in the organs of the male reproductive system (prostate and seminal vesicles of rat and hamster), representing through the visualization of adrenergic fibres (Falck method), cholinergic fibres (Martinez-Rodriguez method) and by immunohistochemical methods to detect the P substance and the CGRP (PAP) in glandular structures. The adrenocholinergic and peptidergic mediators have a growing interest for their synergic action in the control of contractility, vasodilatation and most likely, of the secretory activity of the epithelium, probably expressed by endocrine-paracrinous mechanisms.
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