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Articles by Andrea M. Weiler
Total Records ( 2 ) for Andrea M. Weiler
  Andrea M. Weiler , Qingsheng Li , Lijie Duan , Masahiko Kaizu , Kim L. Weisgrau , Thomas C. Friedrich , Matthew R. Reynolds , Ashley T. Haase and Eva G. Rakasz
  Here we report the results of studies in the simian immunodeficiency virus (SIV)-rhesus macaque model of intravaginal transmission of human immunodeficiency virus type 1 in the setting of genital ulcerative diseases. We document preferential association of vRNA with induced ulcers during the first days of infection and show that allogeneic cells of the inoculum traffic from the vaginal lumen to lymphatic tissues. This surprisingly rapid systemic dissemination in this cell-associated SIV challenge model thus reveals the challenges of preventing transmission in the setting of genital ulcerative diseases and illustrates the utility of this animal model in tests of strategies aimed at reducing transmission under these conditions.
  Jonah B. Sacha , Matthew R. Reynolds , Matthew B. Buechler , Chungwon Chung , Anna K. Jonas , Lyle T. Wallace , Andrea M. Weiler , Wonhee Lee , Shari M. Piaskowski , Taeko Soma , Thomas C. Friedrich , Nancy A. Wilson and David I. Watkins
  The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrate that this discrepancy in presentation is not related to immunodominance but instead is due to differential requirements for epitope generation. These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein.
 
 
 
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