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Articles by Amr Amin
Total Records ( 7 ) for Amr Amin
  Amr Amin , Alaaeldin A Hamza , Sayel Daoud and Waleed Hamza
  Cadmium (Cd) is an environmental and industrial cumulative pollutant that most affects many organs specially the liver. The protective effect of Spirulina, filamentous blue green algae, on Cd – induced oxidative stress and hepatotoxicity was evaluated in male rats. Oral administration of water extract of Spirulina for seven days followed by an acute toxic dose of Cd (3.5 mg kg b.wt.¯1), reduced the hepatotoxicity and attenuated the Cd-induced oxidative stress. Spirulina treatment showed marked reduction in serum aminotrasferase activities and elevation in lipid peroxidation and recovery of the endogenous levels of antioxidants following Cd-intoxication. The Cd-induced hepatic histopathological changes were also minimized with the tested extract. These results suggest that Spirulina algae might play a role in reducing the toxic effect of Cd and its antioxidant properties seems to mediate such a protective effect.
  Mariam Al Shamsi , Amr Amin and Ernest Adeghate
  The role of vitamin C on diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin C on some of the metabolic parameters of experimental diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (60 mg kg¯1 body weight at 12 weeks of age). Vitamin C (10, 50, 100 mg kg¯1 body weight) was administered orally for a period of four weeks to normal and diabetic male Wistar rats. In some experiments Vitamin C was given either before or after the induction of diabetes mellitus. Glucose tolerance test (GTT) was performed on fasted normal, diabetic and vitamin C-treated rats at the end of the experimental period. Blood sugar level and weight were also recorded on a weekly basis for each rat in different groups. Vitamin C significantly (p<0.05) reduced blood glucose level and decreased weight gain in experimental diabetes mellitus at all doses when compared to untreated rats. This beneficial effect of vitamin C on the hyperglycemia of diabetic rats was dose-dependent. Moreover, vitamin C also improved GTT in diabetic rats compared to untreated diabetic rats. In conclusion, Vitamin C may play a role in insulin metabolism and thus be a useful adjuvant therapy in diabetes mellitus.
  M-Ali H. Al-Akhras , Amr Amin , Karima Mohammad , Fedae Al-Haddad and Allaaeldin Hamza
  New photosensitizers have been extracted from the flowers and aerial parts of the Cichorium Pumilum Jacq (chicory). Chicory grows naturally in local wild areas and is known to cause quick death of only white sheep during its flowering season in autumn. Some of those isolated photosensitizers are yet to be further characterized. Preliminary investigations show a high degradation of isolated photosensitizers under direct sunlight (solar irradiance 450-950W m¯2). This in vitro study also shows a very high photohemolysis rate at a concentration of 0.95 mg mL¯1. The extracted compounds are also found to be temperature dependent. Multiple absorption peaks are also shown for tested extract both in ultraviolet region (at the wavelengths 314, 360nm) and in the visible region (at 445, 492 and 667nm). Results of the present investigation clearly show the potential of the light- and temperature-dependent extracted compounds as a new member of the photodynamic therapeutics. It is possible therefore that the claimed chicory-induced death of white sheep is simply a direct result of phototoxicity.
  M-Ali H. Al-Akhras , Amr Amin , Karima Mohammad , Fedae AlHaddad and Alaaeldin Hamza
  Addition of inulin and hydrogen peroxide to new photosensitizers extracted from the flowers and aerial parts of the chicory (Cichorium Pumilum Jacq) have been investigated. Some of the isolated photosensitizers remain unidentified compounds. Chicory extracts are found to be dependent on light and temperature. Higher photohemolysis rate was noticed under the influence of light as compared to temperature. The effect of H2O2 on phototoxicity reported in this study showed a rapid reduction in the fractional hemolysis percentage at higher temperature. Compared to erythrocytes with higher concentrations and under the influence of solar irradiance 505.29±24.96w/m2, erythrocytes with lower concentrations of inulin and H2O2 were ruptured faster. Samples with 0.95mg/ml of herb extract and different concentrations of inulin (1mg/ml – 2mg/ml) shows no temperature effects at 40°C in the absent of sunlight.
  Amr Amin
  The present study investigated the chemopreventive effects of the water extract of chlorella on the development and growth of DMBA-induced mammary tumors. Female rats were daily administered vehicle control or chlorella either at 0.5 g or at 1.0 g kg-1 body weight starting at age of 35 days and continued to the end of the experiment. At age of 50 days breast tumor was induced by administering DMBA at 25 mg kg-1 body weight. Similar DMBA dose was administered to DMBA-alone group at age of 50 days. As a control for chlorella treatment one group (chlorella-alone) was administered chlorella at 1.0 g kg-1 body weight starting at age of 35 days and continued to the end of the experiment. Animals were then followed for 15 weeks. Effects of chlorella on the expression of proliferating cell nuclear antigen (PCNA), p53 and estrogen receptor (ER) were investigated in mammary tissues of control and experimental groups using immunohistochemistry. Present data demonstrated that chlorella treatment restored the normal expression levels of PCNA and ER. Chlorella also significantly increased cell death as assessed by the terminal deoxynucleotidyl transferase-mediated triphoshate nick-end labeling (TUNEL) analysis. In conclusion, the protective role of chlorella’s water extract against carcinogen-induced breast cancer seems to be mediated through its anti-proliferative and pro-apoptotic properties.
  Amr Amin
  The present study was designed to evaluate the protective effect of Chlorella against liver oxidative damage induced by oral administration of 7,12-dimethylbenz[a]anthracene (DMBA) to female Wistar rats. Animals of protected groups were orally administered with dried powdered of Chlorella suspended in warm water at two selected doses; 0.5 and 1.0 g kg-1 b.wt. Water extract of chlorella tablets (Wakunaga of America Co., Ltd. Mission Viejo, CA, USA) was given to rats two weeks before DMBA administration and was continued for 15 weeks after cancer induction. Administration of DMBA (25 mg/rat) caused a significant increase of lipid and protein oxidations and significantly altered the levels of liver antioxidants. Treatment with chlorella extract has significantly prevented DMBA-induced oxidative changes in liver. Levels of MDA and P.carbonyl were significantly reduced after administration of chlorella extract. Chlorella has also restored normal level of indigenous antioxidants such as CAT, GSH, GST and SOD. The present results also show a high antioxidant activity of chlorella extract. It is therefore concluded that due to its potent antioxidant properties, chlorella modulates the DMBA-induced hepatic oxidative stress that is normally associated with induced-breast cancer in rats.
  Amr Amin
  In this study, the effect of phospholipases, Cobra Venom Factor (CVF) on the morphology of testis in mice as well as on some mineral contents was investigated. Mineral analysis shows changes in the concentration of many elements. This report however, will only discuss calcium, potassium and phosphorus and their possible roles during testis development. Toxin administration results in severe structural damage to the testis. These toxin-induced abnormalities are associated with a reduction in the intracellular concentrations of calcium, potassium and phosphorus in testis cells. Inhibition of calcium suggests a signaling-mediated role of the CVF-induced effect on the testis of intoxicated mice. Potassium depletion is believed to mediate cellular deformation through hyperpolarization of the plasma membrane. Reduction of the intracellular phosphorus causes many physiological abnormalities within testis cells as a result of the reduced production of internal cellular regulators that are mostly phosphorylated.
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