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Articles by Amjad Hameed
Total Records ( 4 ) for Amjad Hameed
  Amjad Hameed , Salman Akbar Malik , Nayyer Iqbal , Rubina Arshad and Shafqat Farooq
  Influence of oxidative stress induced by exogenous application of hydrogen peroxide on initial leaf and coleoptile growth in etiolated wheat seedlings was studied. Leaf and coleoptile growth parameters (mean fresh weight and length) showed a transient stress effect during very initial age, becoming non-significant (P>0.05) in later age (8th day). Mean leaf fresh weight increased steadily after 5th day in both stressed and control seedlings, however the magnitude was lower in stressed seedlings and the difference was non-significant (p>0.05). Mean coleoptile fresh weight was significantly (p<0.01) lower in stressed seedlings on all days except on 6th and 8th day where the difference was non-significant (p>0.05). Mean leaf and coleoptile length were significantly (p<0.01) lower in stressed seedlings during 5 to 7th day, however the difference was non-significant (p>0.05) on 8th day. Stress effect was more pronounced on 5th day in case of leaf and coleoptile length and coleoptile fresh weight. Collectively oxidative stress induced by exogenous application of hydrogen peroxide induces a transient and finally a non-significant effect on initial leaf and coleoptile growth, which indicated the adaptation of seedlings to applied stress.
  Amjad Hameed , Salman Ahmad Malik , Fazli-Rabbi , Aysha Sharif , Nasir Ahmad , Farwa Nurjis , Shafaqat Ali and Javed Anver Qureshi
  This study was undertaken to find prevalence of diabetic complications and influence of age, sex, family history, duration, glycemic control and obesity on these complications in 1104 diabetic patients. Late diabetic complications were present in 76% cases. The prevalence of hypertension was 28.846%, retinopathy 25.962%, neuropathy 24.038%, nephropathy and ischemic heart disease 8.654%, polyarthritis 6.731%, angina and urinary track infection 5.769%, dermatitis 4.808% and atherosclerosis 1.923%. Overall 74% cases had poor glycemic control. An increase in mean (SD) (227.722 (74.521) vs. 222.360 (64.386) mg/dl) and most frequent (mode) (340 vs. 200 mg/dl) random blood glucose of complicated cases compared with non complicated cases was observed. There was no difference in mean (SD) age (50.768 (13.715) vs. 50.800 (12.845) years) and median age (50 vs. 50 years) of complicated and non-complicated cases while most frequent age (mode) (45 vs. 40 years) was higher in complicated cases. The mean (SD) (43.240 (12.965) vs. 46.760 (13.694) years), median (43 vs. 49 years) and most frequent age at diagnosis of diabetes (mode) (40 vs. 46 years) was lower in complicated cases compared with non-complicated cases. The prevalence of diabetic complications was low (66.667%) in diabetic patients with family history of diabetes as compared to diabetic patients without family history of diabetes (79.221%). An increased percentage of complicated cases in males (80.33%) as compared to female patients (72.09%) were observed. Mean (SD) duration of diabetes was higher in complicated diabetic patients (7.585 (5.730) years) as compared to non-complicated diabetic patients (4.080 (4.551) years). There was an increase in percent-complicated cases with an increase in duration of diabetes and both parameters showed a positive regression (R2 = 0.84). Obese diabetic patients have 13.555 and 14.461% more chance of developing diabetic complications compared with normal and lean diabetic patients respectively. It was concluded that poor glycemic control, early age at diagnosis, gender (male), duration of diabetes and obesity are the factors which can increase the risk of developing diabetic complications.
  Amjad Hameed , Faiz Batool , Tahira Iqbal , Tayyba Tabassum Baig and Javed Anver Qureshi
  This study was based on biodisposition kinetics of ofloxacin in Pakistani healthy female volunteers after oral administration. Ten healthy female volunteers were included in this study. The blood samples of each volunteer were collected after oral administration of ofloxacin. The concentration of ofloxacin in blood samples was measured by microbiological assay. The mean (SE) values of time to peak (tmax), peak concentration (Cmax), absorption half life (t1/2α), absorption rate constant (ka), elimination half life (t1/2), elimination rate constant (K10β), were 1.012 ± 0.176 h, 0.907 ± 0.126 μg ml-1, 0.516? 0.093h, 13.593?2.936L h-1, 2.996 ± 0.567h and 0.291 ± 0.693 L h-1 respectively. The mean (SE) values for area under curve (AUC), clearance (CL), volume of distribution (Vd) and mean resident time (MRT) were 4.358 ± 0.771 1itter, 53.470 ± 11.068 l h-1, 214.41?49.127 litter and 5.030 ± 0.705 h respectively. Values of parameters like, volume of distribution, total body clearance and absorption rate constant were higher, while elimination half life, AUC, Cmax, and tmax were lower in local population as compared with foreign studies. There was no influence of body surface area on total body clearance of ofloxacin (R2=0.0581). There was an increase in body clearance of ofloxacin (R2=0.2236) and area under curve (AUC) for ofloxacin (R2=0.258) with increasing body surface are of volunteers. Therefore body surface area of volunteers may slightly influence the total body clearance and area under curve for ofloxacin. These gender-related differences mainly low body weight and surface area in females may warrant dosage adjustments.
  Amjad Hameed , Salman Ahmad Malik , Fazli-Rabbi , Aysha Sharif , Nasir Ahmad , Wajahat Hussain , Hassan Akhtar Bokhari , Shafaqat Ali , Farwa Nurjis , Ahmad Mukhtar Khalid and Javed Anver Qureshi
  The epidemiology of diabetes mellitus was studied in and around Faisalabad, Pakistan. The age of diabetic patients ranged from 5 to 82 years. The mean (SD) values for age, age at diagnosis of diabetes and duration of diabetes were 50.798(13.449), 44.086(13.163) and 6.744(5.668) years respectively. The most frequent age, age at diagnosis and duration of diabetes was 45, 40 and 10 years respectively. Family history of diabetes was observed in 25.962% patients. There was no association among family history, age at diagnosis of diabetes and gender. Prevalence of obesity was 28% while 30% diabetic patients were lean. In obese group a high prevalence of female patients (79.310%) was observed as compared with males (20.689%). Type 2 diabetes was (98.077%) the most prevalent type and was more common in females. Preponderance of females (86.207% vs 13.793%) was found in age group of 35-44 years based on age at diagnosis of diabetes. Any kind of late diabetic complications were observed in 76% diabetic patients. Finally obese females with diabetic history in their families should be diagnosed for diabetes during 35-44 years of age. This practice may be of great help in early diagnosis and then after proper management of diabetes.
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