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Articles by Amjad Ali Khan
Total Records ( 4 ) for Amjad Ali Khan
  Amjad Ali Khan , Mohammad A. Alzohairy and Abdelmarouf H. Mohieldein
  This study was conducted to analyse the possible antidiabetic effects of camel milk in streptozotocin (STZ)-induced diabetic rats by assaying liver and kidney clinical function parameters. Administration of streptozotocin (55 mg kg-1 b.wt.) to the experimental groups of rats resulted in marked detectable changes. The rats were fed daily with fresh camel milk by feeding bottles for 30 days. The effects of camel milk on blood glucose, serum proteins, urea, uric acid, creatinine, lipid profile and the activities of diagnostic marker enzymes of liver function and Alkaline Phosphatase (ALP) were examined in the plasma/serum of control and experimental groups of rats. Camel milk feeding to diabetic rats significantly reduces the levels of blood glucose, urea, uric acid and creatinine and increases the activities of albumin, albumin/globulin ratio and restores all liver function marker enzymes and lipid profile to near control levels. The present study shows that feeding of camel milk to diabetic rats has antihyperglycemic effects and consequently may alleviate liver and renal damage associated with streptozotocin-induced diabetic rats.
  Amjad Ali Khan and Mohammad A. Alzohairy
  Camel milk has been widely used in a number of countries as a food additive and for curing some commonly occurring diseases. Recently, camel milk has been deeply studied for its special properties because of higher hepatoprotective, insulin like and antibacterial activities. These properties distinguish camel milk from milk of other animals. The present study was carried out to investigate the protective effects of camel milk against CCl4-induced hepatotoxicity which lead to biochemical alterations in liver function of male albino wister rats. White albino male rats (200-250 g) were divided into 5 groups, a normal control water group, a control camel milk group and three CCl4-intoxicated groups treated with or without camel milk. Protective roles of camel milk were analyzed by assaying the liver function parameters as serum aminotransferases, alkaline phosphatase, serum proteins and cholesterol levels. Histopathological examinations were also studied in all groups of rats by microscopy. Data showed that intraperitoneal administration of CCl4 (1 mL kg-1 b.wt.) resulted in statistically significant increase in the serum levels of aminotransferases and change in serum protein, albumin and cholesterol levels which approach to normal levels after the treatment with raw camel milk. Furthermore, histopathological studies reveal that camel milk treatments significantly reduce the incidence of liver lesions induced by CCl4. Our findings demonstrate that CCl4 exposure alters liver function biochemical parameters, which shift towards normal values after treatment with camel milk. So camel milk has a good potent for curing some liver diseases.
  Mohammed A. Alsahli , Ahmad Almatroudi , Amjad Ali Khan , Fahad Abdulrahman Alhumaydhi , Faris Alrumaihi and Arshad Husain Rahmani
  Background and Objective: Figs are recognised to contain a number of pharmacological properties without any adverse effect. The present study aimed to evaluate the protective role of fig fruit extract on CCl4-induced hepato-toxicity. Materials and Methods: The mice were randomly divided into 4 groups, Group I mice, vehicle treated were kept on normal diet and served as normal control. Group II mice, received fig extract only, Groups III, received CCl4 only and served as disease control group. Group IV mice, labelled as treatment group, received CCl4+fig fruit extract (100 mg kg–1 b.wt.). Results: CCl4-induction causes significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) level and decrease in antioxidant enzymes levels. Administration of fig extract significantly restore the CCl4-induced alterations in the liver enzymes and antioxidant enzymes and such differences were statically significant (p<0.05). Histopathology of the liver tissue revealed that administration of fig fruits extract reduced inflammatory cell infiltration and blood vessel dilation and showed role in the maintenance of hepatocytes architecture whereas, severe tissue alterations was noted in CCl4 treated group. Conclusion: The overall findings, indicate that fig fruit extract is useful in preventing liver injury against CCl4-induced hepato-toxicity through its antioxidant enzyme activities and shows role in the maintenance of hepatocyte architecture.
  Saleh A. Almatroodi , Ahmad Almatroudi , Fahad Saleh Almasnad , Amjad Ali Khan , Ali Yousif Babiker , Abdulmohsen M. Alruwetei and Arshad Husain Rahmani
  Background and Objective: Curcumin, an active compound derived from turmeric (Curcuma longa) was noticed to have health promoting effects through modulating various biological activities. The present study was carried out to assess the hepatoprotective effect of curcumin in CCl4-induced hepatotoxicity rats. Materials and Methods: Liver function enzymes activity was evaluated using the spectrophotometric method. The levels of inflammatory markers were measured using the enzyme-linked immunosorbent assay (ELISA) method. Moreover, antioxidant enzymes (Catalase, glutathione-S-transferase) were assayed in the serum calorimetrically. Haematoxylin-eosin staining was performed to examine the histopathological changes. In addition, expression of vascular endothelial growth factor (VEGF) protein was evaluated through immunohistochemical staining. Statistical comparison between groups was made via using SPSS software by matching analysis of variance. A p<0.05 was measured to be statistically significant. Results: Oral administration of CCl4 into rats for 8 weeks had resulted in significant decrease of the serum level of the antioxidant enzymes including superoxide dismutase (SOD) and catalase. It had also significantly increased the serum level of the liver function enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and proinflammatory markers. Oral administration of 50 mg kg1 b.wt., of curcumin evidences a significant protection against CCl4 induced liver damage as measured in terms of liver function enzymes, antioxidant enzymes, inflammatory markers and histopathological parameters. Moreover, curcumin treatments protected against CCl4-induced liver damage by maintaining histological damage. Conclusion: Based on these findings, it is concluded that antioxidant effect of curcumin could protect liver injury and normalize the architecture of hepatocytes against CCl4 induced toxicity
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