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Articles by Amit K. Tiwari
Total Records ( 2 ) for Amit K. Tiwari
  Hazem Ramadan , Byungjin Min , Amit K. Tiwari , Gopal Reddy , Abiodun Adesiyun , Arthur Hinton Jr. and Woubit Abdela
  This study was conducted to determine the antimicrobial activity of methanol and ethanol extracts of peels of pomegranate (Punica grana), orange (Citrus siensis) and lemon (Limona taris) against four foodborne pathogens (Listeria monocytogenes, Salmonella Typhimurium, Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) and a food spoilage bacterium (Pseudomonas fluorescens. Inhibition tests were conducted in vitro using the disc diffusion and minimum inhibition concentration (MIC) assays with the Bioscreen Microbiology analyzer. The study also evaluated the antimicrobial activity of the extracts in situ by determining CFU/ml of bacteria recovered from rinsates of chicken skin treated with the peel extracts and by examining the microflora of treated skin samples using scanning electron microscopy (SEM). The antimicrobial activity of all extracts, except the pomegranate ethanol extract, were dependent on the concentration of extract that the bacteria were exposed to during the trials. Treating the inoculated chicken skin with 5 mg/ml of either the five extracts produced significant (p<0.01) reductions in CFU/ml of MRSA, L. monocytogenes and P. fluorescens recovered and the MRSA findings were supported by SEM observations. The antimicrobial activity of peel extracts of pomegranate, orange and lemon indicates that these extracts may be used as sanitizers to reduce microbial contamination of some foods and processing.
  Uma Shankar Sharma , Harlokesh Narayan Yadav , Vishwa Mohini Khare , Surender Singh , Yogendra Kumar Gupta and Amit K. Tiwari
  Background and Objective: Cisplatin is a potent anti-cancer agent, however, its usage is limited due to its nephrotoxicity. To prevent cisplatin induced kidney toxicity we used a combination of dietary plant extracts, particularly, hydro-alcoholic extract of Tribulus terrestris (TT), Boerhaavia diffusa (BD) and Terminalia chebula (TC) in rats. Materials and Methods: Animals (n = 6 per group) were randomly assigned into six groups: A normal control, cisplatin control, the drug-combination armat doses of 198, 300 and 600 mg kg1 of equal ratio of each of TT, BD and TC and the combination of 300 mg kg1 per se group. All treatments were given orally once a day for 10 days. Nephrotoxicity was induced by single dose of cisplatin 8 mg kg1, i.p on the 7th day. Blood urea nitrogen (BUN), serum creatinine, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx), renal histopathology, liver fatty acid binding protein (L-FAB), kidney injury molecule-1 (Kim-1) and platinum accumulation in kidney tissue were determined. Results: The pre-treatment of the combination of equal ratio of TT, BD and TC at 198, 300 and 600 mg kg1 significantly (p<0.05) attenuated the cisplatin-induced nephrotoxicity, as indicated by decrease in BUN, serum creatinine, MDA and an increase in the concentration of GSH, SOD and GPx whereas combination100 and 200 mg kg1 significantly decreases Kim and L-FABP and combination of 600 mg kg1 significantly decreases the platinum accumulation in treated groups as compare to cisplatin control group. Conclusion: Our results suggest that the combination of TT, BD and TC may be efficacious in attenuating cisplatin-induced nephrotoxicity by decreasing the renal level of platinum, reactive oxygen species (ROS) and oxidative stress.
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