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Articles by Amirhossein Sahebkar
Total Records ( 3 ) for Amirhossein Sahebkar
  Majid Ghayour-Mobarhan , Amirhossein Sahebkar , B.J. Starkey , C. Livingstone , T. Wang , D.J. Lamb and G.A.A. Ferns
  There are limited data on the effects of statins on serum vitamin E status in dyslipidaemic patients, and no comparisons between statins have been published previously. We have investigated the effect of Atorvastatin and Simvastatin on serum vitamin E status in dyslipidaemic patients. A total of 20 dyslipidaemic patients (14 males, 6 females, mean age 49.15±3.28 years), previously not treated with a lipid lowering agent, were recruited into the study. These patients were randomized to treatment group and received either: Simvastatin 10mg/day (n = 11) or Atorvastatin 10mg/day (n = 9) for 4 months. The control group comprised 14 patients from the same clinic, who were given lifestyle advice, but whose drug treatment remained unchanged for the duration of the study. Serum concentrations of vitamin E, high sensitivity C-reactive protein (hs-CRP) and fasted lipid profiles pre- and post-treatment were measured in all subjects. There were the expected significant reductions in serum lipids in the patients treated with either statin (P<0.001). Overall statin treatment was also associated with a significant reduction in serum vitamin E (21%, P<0.001) and hs-CRP (45%, P<0.05). There was no significant change in these parameters in the control patients. The serum vitamin E / total cholesterol ratio was not significantly altered in patients receiving Atorvastatin, or Simvastatin despite the significant reduction in serum vitamin E. No change in vitamin E status was observed in the controls.
  Mehrdad Iranshahi , Farhad Kalategi , Amirhossein Sahebkar , Alireza Sardashti and Bernd Schneider
  Three new sesquiterpene coumarins, namely, farnesiferone B (1), flabellilobin A (2) and flabellilobin B (3), together with nine known compounds, ligupersin A, 7-epi-gamma-eudesmol, persicasulfide A, conferdione, umbelliprenin, conferone, feselol, lehmferin and farnesiferol B were isolated from the roots of Ferula flabelliloba Rech. f. & Aell. (Apiaceae). The structures of these compounds were elucidated by various 1- and 2-D NMR techniques as well as HREIMS.
  Seyyed Majid Bagheri , Amirhossein Sahebkar , Ahmad Reza Gohari , Soodabeh Saeidnia , Maryam Malmir and Mehrdad Iranshahi
  Several Ferula (Umbelliferae) species have been used in Iranian traditional medicine as antiflatulent, antispasmodic, anticonvulsant, expectorant, etc. In the present study, cytotoxicity and anticonvulsant activity of the methanol extracts from several Ferula species were evaluated. Air-dried samples of different parts of these plants (Ferula diversivittata Regel & Schmalh. (roots), Ferula persica Willd. (aerial parts), Ferula ovina (Boiss.) Boiss. (roots), Ferula badrakema Kos.-Pol. (roots), Ferula diversivittata (flowers), Ferula latisecta Rech. F. & Aell. (roots), and Ferula badrakema (fruits)) were macerated with methanol for 3 days. The mixtures were then filtered, concentrated and dried. For determination of the cytotoxicity of the extracts and also the oleo-gum-resin of F. assafoetida L., the brine shrimp (Artemia salina) was employed as a model assay system since it provides a convenient in-house pre-screening method for evaluating general cytotoxicity. The methanol extracts of different Ferula species and the oleo-gum-resin of F. assafoetida exhibited cytotoxic effect with LC50 values in the range of 6-321 μg/mL. For the anticonvulsant testing, seizure was induced by injection of pentylenetetrazole (PTZ), 90 mg/kg intraperitoneally (i.p.). This dose was given to 10 groups, each consisting of 6 mice, which were pretreated i.p. with the extracts (300 mg/kg), Diazepam (10 mL/kg) or saline (10 mL/kg). The results showed that none of the tested Ferula species can prevent PTZ-induced seizure at the used dose. In conclusion, all of the extracts and the oleo-gum resin of F. assafoetida showed dose-dependent cytotoxicity which was highest in F. badrakema fruits and lowest in F. badrakema roots. Our findings also revealed that the methanol extracts and F. assafoetida oleo-gum resin do not possess anticonvulsant activity.
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