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Articles by Amir Ghaemi
Total Records ( 3 ) for Amir Ghaemi
  Amir Ghaemi , Kasra Hamdi , Mansoureh Togha , Hadi Kazemi and Ali Gorji
  The Matrix Metalloproteinase Proteins (MMPs) comprise a large group of endoproteinases that cleave most, if not all, components of the extracellular matrix. The activities of MMPs are modulated by manipulation in the levels of natural MMP inhibitors, the “Tissue Inhibitors of Metallo Proteinases” (TIMPs). In a pathological processes of Multiple Sclerosis (MS), the MMP-2 and 9 (Gelatinase) are over expressed and balance of TIMP and MMP expression is perturbed, leading to locally increased proteolytic activity of Gelatinase and uncontrolled degradation of the Blood Brain Barrier (BBB) and myelin basic protein. Therefore, Gelatinase are the main mediators in the evolution of MS and TIMP has been proposed as a novel therapeutic target for MS therapy.
  Amir Ghaemi , Alijan Tabaraei , Pooria Gill , Hoorieh Soleimanjahi and Ali Gorji
  The emerging aim of drug delivery requires the bioactive or therapeutic molecule to be protected from degradation and reach its target cell and intracellular location. Target specificity of nanoparticles is a prerequisite to attain the concentration of therapeutic agent required for therapeutic efficacy in the target tissue while minimising adverse effects on other parts of the body. Therefore, there is an urgent need for improvement of more effective drug delivery systems to direct the anticancer drugs to cancer cells, specifically. In the paper, we have described advantages of Lambda bacteriophage over other drug delivery vectors and proposed it as promising drug delivery vehicle.
  Alireza Shoae Hassani , Nour Amirmozafari , Negar Ordouzadeh , Kasra Hamdi , Rashed Nazari and Amir Ghaemi
  This study aimed to evaluate the efficacy of semi fermented and non fermented Camellia sinensis extracts (Black and Green tea) and comparison between them against Streptococcus mutans ATCC 25175, S. mitis ATCC 9811 and S. sanguis ATCC 10556 that are responsible for dental caries and bacteremias following dental manipulations. Minimum inhibitory concentrations of both tea extracts were assessed by Well diffusion and Broth dilution methods and examination of cell adherence (Biofilm inhibitory concentrations) was observed on glass slides under phase contrast microscope and colony counts from glass beads. Concentration of 1 mg mL-1 of semi fermented tea extract was completely biofilm inhibitor but biofilm formation by these bacteria was seen 7 days after treatment with 1 mg mL-1 of non fermented Camellia sinensis on glass beads and BIC for oral streptococci treated with this extract was 1.5, 2.5 mg mL-1 of semi fermented and 3 mg mL-1 of non fermented extracts had bactericidal effect on these bacteria. Semi fermented and non fermented Camellia sinensis extracts were able to prevent growth of oral streptococci. Therefore dental caries significantly reduce and the efficiency of semi fermented tea was higher due to rich content of volatile components rather than non fermented extracts.
 
 
 
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