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Articles by Amin Ismail
Total Records ( 2 ) for Amin Ismail
  M.H. Nurulhuda , Azrina Azlan , Amin Ismail , Zulkhairi Amom and Faridah Hanim Shakirin
  The present study was designed to explore the possible cholesterol lowering effect of Sibu Olive (SO) supplementation on cholesterol level and atherosclerosis inhibitory effect in hypercholesterolemic rabbits. A total of five groups (n = 7); NC (normal diet), PC (normal diet+0.5% cholesterol), HS (hypercholestrolemic diet+10 mg kg day-1 simvastatin), HF (hypercholsterolemic diet+5% fullfat SO) and HD group (hypercholesterolemic diet+5% defatted SO) were established. Body weight and lipid profile analysis [total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)] were compared to PC. There was rise in body weight changes (1.75-2.24 kg) of the animals. The HD group showed significant reduction in total cholesterol (96.3%) and LDL-C (26.5%) together with increment in HDL-C (46.8%) relative to PC. Furthermore, the atherosclerotic plaque formation in HD group diminished by 79.4% compared to PC. The possible cholesterol lowering effect was contributed by the presence of polyphenols such as phenolic acids, flavonoids, anthocyanidins and anthocyanin of the SO fruit. Hence, these findings are beneficial as it provide alternative means to treat hypercholesterolemia and atherosclerosis.
  Farhana Aminuddin , Faisal Ali , Amin Ismail , Chong Pei Pei and Muhajir Hamid
  Cocoa, the fruit of Theobroma cacao plant is traditionally used in the folk medicine as a pharmaceutical for blood pressure reduction and cardiovascular diseases prevention. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) is widely known to improve insulin sensitivity and is thereby being used as a major drug target for the treatment of type 2 diabetes mellitus. The present study investigated the anti-diabetic/anti-obesity effects of cocoa polyphenol-rich extract (CoPE) using obese-diabetic rats (Sprague Dawley rats). Sprague Dawley rats received either normal diet, high-fat diet or high-fat diet with additional cocoa polyphenols for 8 weeks. After the end of the treatment, body weight, plasma glucose and insulin were measured. Furthermore, mRNA and protein levels of PPARγ were measured in skeletal muscle and white adipose tissue. Compared to the high-fat diet group, increases in body weight, plasma glucose and insulin were significantly suppressed for CoPE-treated groups. Furthermore, compared to the high-fat diet group, the PPARγ mRNA level was significantly higher in both skeletal muscle and white adipose tissue for CoPE groups. Protein expression of PPARγ in CoPE groups was also significantly higher compared to the high-fat diet group. In conclusion, the anti-diabetic mechanism of actions of CoPE along with metformin hypoglycemic drug is partially attributed to increase expression of PPARγ in skeletal muscle and adipose tissue. These results suggest that CoPE could be a useful phytomedicine agent for alleviating insulin resistance.
 
 
 
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