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Articles by Amel O. Bakhiet
Total Records ( 2 ) for Amel O. Bakhiet
  Warda S. Abdel Gadir , Mohy Edeen , D. Abu Alazaim , Amel O. Bakhiet and I.M.T. Fadlalla
  This study was done on 40 Bovans-type chicks to investigate the possible toxic effects of the therapeutic doses of the antimalarial drugs, Quinine and Fansidar and their combined doses. After two weeks (adaptation period), the drugs were dissolved in distilled water in concentrations of 4.33 mg mL day-1 for Quinine, 4.19 mg mL day-1 for Fansidar and their mixture (4.33 mg Quinine plus 4.19 mg Fansidar) mL day-1 and given orally to Bovans chicks for two weeks. The effects on growth and tissues were investigated. After one week, there was no change in growth and at post-mortem examination, there was congestion of liver in all tested chicks and haemorrhage on the heart of chicks that had been given Fansidar. Serobiochemical changes were increase in the activities of AST, ALT and in concentration of albumin, uric acid, total protein and globulin and decrease in cholesterol levels. There were decreases in haemoglobin, PCV, MCV and MCH values. At the end of two weeks, there was depression in growth of tested chicks, degeneration of the liver of chicks that had been given Quinine and mixture of Quinine plus Fansidar and cardiac haemorrhage in chicks that had been given fansidar and or quinine plus fansidar with increases in AST, ALT activities and in total protein concentration with decreases in globulin levels and PCV values.
  Warda S. Abdel Gadir , Fathia Mohamed and Amel O. Bakhiet
  A study is described in which petroleum ether, ethanol and water extracts from Tamarindus indica ripe fruit and Piper nigrum seed in different concentrations (10-100%) were evaluated for their possible antibacterial activity against four standard pathogenic microorganisms, Staphylococcus aureus (gram-positive bacterium), Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi (gram-negative bacteria). The ethanol extract from T. indica fruit in different concentrations exhibited higher activity against all test bacteria than that from P. nigrum seed and that the activity is concentration-dependent. Petroleum ether extract from P. nigrum seed in different concentrations had no activity against E. coli, Ps. aeruginosa or S. typhi but had activity against S. aureus (inhibition zones 12-15 mm). Petroleum ether from T. indica fruit in concentrations of 10-100% had no antibacterial activity against E. coli and Ps. aeruginosa but the growth of S. aureus and S. typhi was only inhibited by 50% concentration of petroleum ether extract (inhibition zones, 5 mm). Water extract from T. indica fruit at 100% concentration produced inhibition zones at 14-15 mm for E. coli and Ps. aeruginosa, respectively, but had no activity against S. aureus or S. typhi. Water extract in 100% concentration from P. nigrum seed caused inhibition zones at 15 and 12 mm against S. aureus and S. typhi but had no activity against E. coli or Ps. aeruginosa. These findings were compared with those produced by gentamicin (10 μg), a reference antibiotic.
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