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Articles by Ambreen Ijaz
Total Records ( 2 ) for Ambreen Ijaz
  Bazghah Sadaf Siddiqui , Haq Nawaz Bhatti , Ambreen Ijaz , Saba Rasheed and Bushra Saleem
  Acetylsalicylic acid is a non-steroidal anti-inflammatory drug. Urinary excretion of ASA (as free salicylic acid) was investigated in twelve healthy male volunteers after an oral administration of 600 mg dose. Urine samples were collected upto 10 h. The concentration of drug was determined colorimetrically and mean ±SE value in urine was found to be 37.55±0.418 μg mL–1. The values for diuresis and rate of excretion was 0.028±0.006 mL min–1 kg–1 and 0.849±0.226 μg min–1 kg–1. The amount of free SA excreted was 5.40±1.15 mg. The % dose excreted was 0.92±0.19%. Cumulative amount and % cumulative dose excreted was found to be 17.74±2.91 mg and 5.47±0.78%. There is slight variations in urinary excretion data when compared with foreign investigated values.
  Saba Rashid , Haq Nawaz Bhatti , Ambreen Ijaz , Bazgha Sadaf and Sarfraz Ahmed
  Renal clearance of endogenous creatinine and acetylsalicylic acid was investigated in 12 healthy male volunteers. Blood and urine samples were collected at pre-determined time intervals. The concentration of acetylsalicylic acid (as salicylates) and creatinine in plasma and urine were determined colorimetrically. Mean ±SE values were found to be, for diuresis 0.031±0.011 mLmin‾1 kg–1, Plasma concentration of creatinine and salicylic acid 15.11±0.166 μg mL–1 and 29.38±0.12 μg mL–1, urine concentration of creatinine and salicylic acid 855.73±1.53 μg ml–1 and 38.30±0.43 μg mL–1, renal clearance of creatinine and salicylic acid 1.52±0.08 ml min–1 kg–1 and 0.063±0.02 mL min–1 kg–1 and clearance ratio 0.054±0.016. The results indicated that there is less renal clearance of acetylsalicylic acid in local environment when compared with values given in literature.
 
 
 
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