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Articles by Amany H. Mansour
Total Records ( 4 ) for Amany H. Mansour
  Amany H. Mansour , Rokia Anwer , Ahmad Darwish , Abdulrahman Fahmi Alshaik and Mohamed Mabed
  Treatment of Acute Promyelocytic Leukemia (APL) with All–Trans Retinoic Acid (ATRA) represents a paradigm in targeted cancer therapy as these drugs cause clinical remission by affecting the stability of the fusion oncoprotein promyelocytic leukemia (PML)/Retinoic Acid Receptor Alpha (RARA). Previous studies have implicated in the main mechanism involved in therapy induced PML/RARA degradation. Investigated the effect of ATRA on the autophagy responses LC3–1, II and Beclin 1 proteins and if ATRA–induced upregulation of autophagy and Beclin 1 in the acute promyelocytic leukemia cells or not. Study included 22 subjects diagnosed as Acute Promyelocytic Leukemia (APL) (M3), also included 20 healthy subjects as a control selected to match the study. Peripheral blood and BM examination, Immunophenotyping, Conventional cytogenetic, Western blotting for LC3-I and LC3-II formation expression and Enzyme Link Immunosorbent Assay (ELISA) kit for Beclin-1 (BECN1). Both beclin-1 and LC3-11 were significantly increased in patient than control group before induction therapy. Proteins induced autophagy LC3-11 was increased after induction therapy than before in APL cells and that indicate autophagic degradation. The present study indicate that the ATRA-induced up regulation of autophagy protein and Beclin-1and LC3-1, 11 in the acute promyelocytic leukemia cells.
  Mohammed Amin Mohammed , Nesreen Moustafa Omar , Amany H. Mansour , Sherin Mohamed Abd El-Aziz and Gamal Othman
  Vitamin D is an important immune modulator that has an emerging role in inflammatory and metabolic liver diseases. An association has been established between low levels of vitamin D and several adverse health outcomes including upper respiratory and enteric infections, viral hepatitis and HIV infections. It exerts protective effects during infections by up-regulating the expression of cathelicidin and β-defensin 2 in phagocytes and epithelial cells. Thus, vitamin D appears to have systemic antimicrobial effects that may be crucial in a variety of both acute and chronic illnesses. In the current study, 25-hydroxyvitamin D3 (25-OHD3) levels were compared among 75 patients with chronic hepatitis B virus infection (Group I), sixty naturally immunized individuals (Group II) and another sixty age and sex-matched healthy controls. Routine biochemical parameters like hepatitis markers, hepatitis B virus serology, hepatitis B virus DNA, 25-OHD3 and Parathormone levels were measured. Patients in group I had a significantly lower 25-OHD level compared with group II and controls (13.9±4.93 vs. 22.1±6.14 and 23.15±8.28 ng mL-1, respectively p<0.001). In contrast, patients in group I had a higher parathyroid hormone level compared with group II and control group (103.14±24.5 vs. 75.14±23.4 and 74.1±20.15 pg mL-1, respectively p<0.001). Also, 25-OHD levels were inversely correlated with hepatitis B virus DNA levels. The observed diminished 25-OHD levels in patients infected with hepatitis B virus may be an indicator of the viral replication status and portends a poor prognosis.
  Mohammed Amin Mohammed , Rokia Anwar , Amany H. Mansour , Emad Elmasry and Gamal Othman
  Obesity is a chronic multi-factorial disease associated with serious increases in adiposity, morbidity and mortality rates. Ghrelin, leptin and adiponectin complexly interact to modulate appetite and mediate metabolic processes. The objective was to evaluate the effects of Bioenteric Intragastric Balloon (BIB) versus conservative therapy (diet and physical exercise) on plasma ghrelin, leptin, insulin and adiponectin in obese subjects. A total of 128 adult consecutive morbidly obese individuals were randomized into: BIB group comprised 84 patients treated with Intragastric Balloon and control group comprised 44 obese patients treated with conservative treatment only. In BIB group, insertion of balloon caused a significant reduction in body mass over a 6-months period compared with the control group. After one month, the levels of ghrelin increased significantly then gradually decreased, reaching the starting level three months after the removal of the balloon. Also, leptin level decreased significantly. In the control group, the corresponding of ghrelin and leptin levels remained relatively stable. In BIB group, adiponectin significantly increased as opposed to a transient increase in the control group. Conclusion: intragastric balloons in association with low-calorie diet are effective, safe, reversible, but short-lasting therapeutic endoscopic intervention in obese patients. The treatment with BIB causes significant changes in the levels of appetite-regulatory hormones beside a body mass reduction, changes in carbohydrate and lipid metabolism and improved co-morbidities.
  Mohammed Amin Mohammed , Nesreen Moustafa Omar , Abdelhadi M. Shebl , Amany H. Mansour , Emad Elmasry and Gamal Othman
  The correlation between celiac disease (CD) and type 1 diabetes (T1D) mellitus has been known for decades. However, the data assessing celiac disease prevalence in type 1 diabetic patients among Arab population especially in Egypt were scarce. This study assessed celiac disease prevalence and its genotypic profile in Egyptian type 1 diabetic patients and their non diabetic relatives and determined effects of gluten-free diet on diabetes control and anthropometry. A total of 500 outpatients {15-49 years; with type 1 DM (300; F/M: 168/132) and their non diabetic relatives (200; F/M: 91/109)} and another 300 age and sex matched healthy control were randomly enrolled and screened for CD by tissue transglutaminase (TTG) antibodies, HLA genotyping and distal duodenal biopsy. The demographic, clinical, anthropometric data and effects of gluten free diet were assessed. CD prevalence was 10.3, 2 and 0.3% in T1D, relative and control groups, respectively. The majority of CD patients (77.42%) carried the HLA-DQ2 in linkage with HLA-DRB1*03 alone (41.9%) or with other alleles (DRB1*01,*04,*07,*08,*09,*13). Eleven patients (35.48%) carried HLA-DQ8 either alone in three patients or with other alleles (DRB1*03,*07 in five and three patients respectively. Only one patient with positive TTG-IgG and normal histopathology had negative DQ2 and DQ8 but positive DRB1*7 and *11 haplotypes. CD is a frequent but commonly under-diagnosed among Egyptian T1D patients. HLA-DQ2 and DQ8 genotypes (in linkage with HLA-DRB1*3 and HLA-DRB1*4 alleles) responsible for CD development are highly prevalent in Egyptian CD patients with T1D.
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