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Articles by Aman B. Upaganlawar
Total Records ( 2 ) for Aman B. Upaganlawar
  Aman B. Upaganlawar and R. Balaraman
  Background: Consumption of dietary constituents containing polyphenols, flavonoids and vitamins are associated with reduced risk of cardiovascular disorders. In the present myocardial infarction was induced in male albino rats by subcutaneous injection of isoproterenol (ISO) (200 mg kg-1) for 2 consecutive days at an interval of 24 h. Result: ISO injected rats showed a significant (p<0.001) increase in total cholesterol, triglycerides and free fatty acids levels in both serum and cardiac tissue. However, a rise in the levels of serum phospholipids was observed in ISO-injected rats. Further, ISO injected rats showed a significant decrease in the level of high-density lipoprotein in serum and PLs levels in the heart. The activities of lecithin: cholesterol acyl transferase and lipoprotein lipase was significantly (p<0.01, p<0.001) decreased and cholesterol ester synthetase was significantly (p<0.001) increased. ISO injected rats also showed significant increase in area of infarction. Administration of Vitamin E (100 mg/kg/day, p.o.) alone and in combination with lycopene (10 mg/kg/day, p.o.) for 30 consecutive days significantly attenuated these alterations and restored the levels of serum and heart lipids, lipid metabolizing enzymes along with area of infarction. Conclusion: These findings indicate that addition of lycopene along with vitamin E showed better effects rather than vitamin E.
  Kiran H. Bhokare and Aman B. Upaganlawar
  Background: The present study was design to screen the neuroprotective effects of Lagerstroemia speciosa L. on painful diabetic neuropathy. Materials and Methods: Diabetes was induced in rats by intraperitoneal injection of single dose of STZ (60 mg kg–1). Neuropathic pain was assessed in diabetic rats by pin prick method, cold allodynia and hot plate method. Pain was developed at 58th day. At the end of experiment animals were scarified and biochemical changes (Lipid peroxidation, reduced glutathione and nitric oxide content) in sciatic nerve were evaluated. Animals were treated with Lagerstroemia speciosa L. extract at two doses (50 and 100 mg kg–1 p.o.) for 58 days. Results: Treatment with Lagerstroemia speciosa L. at doses of 50 and 100 mg kg–1 significantly restored the reduced body weight and elevated blood sugar level. Further the extract of Lagerstroemia speciosa L. showed dose dependent reduction in pain threshold tested by mechanical, cold and thermal hyperalgesia. The level of lipid peroxidation, reduced glutathione and nitric oxide content was significantly prevented. Conclusion:lain The result of present study suggests the antidiabetic, antioxidant and neuroprotectieve property of Lagerstroemia speciosa L. in laboratory animals.
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