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The present study was designed to evaluate the effect of exposure to mixture of four Organophosphate insecticides (OPIs) at dose equaled to No Observed Adverse Effect Level (NOAEL) for 28 day on liver of male rats and their attenuation by vitamin C (V.C). Rats were divided into four groups of six each: control, OPIs, OPIs+V.C and V.C group. The activities of serum aspartate aminotransferase (AST), Alanine Transaminase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were statistically (p≤0.01) increased, while the activity of cholinesterase (ChE) was decreased in rats exposed to OPIs. Supplementation of V.C was mitigating the adverse effects of OPIs but the increased were still significantly (p≤0.05). Body weight and total protein concentration were statistically (p≤0.05) decreased, while relative liver weight was statistically (p≤0.05) increased in OPIs-treated group. In addition, administration of OPIs resulted in damage of liver structures. Combination therapy with V.C significantly (p≤0.05) restored these alterations to within the normal limits and prevents disruptions of liver structures. According to these results, it is suggested that exposure to multi-chemical with a common mechanism of toxicity might cause hazardous effects at NOAEL levels to non-target organisms, including humans.
