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Articles by Amal Mansour
Total Records ( 3 ) for Amal Mansour
  Amal Mansour , Hisham Harb and Mohamed Abdelhafeez
  Homocysteine and some related cytokines are involved in Preeclampsia (PE) pathogenesis but their role in progression of the disease is controversial, accordingly the aim of this study was to evaluate maternal serum Homocysteine levels and relate them to tumor necrosis factor-alpha (TNF-α) and Transforming Growth Factor-beta 1 (TGF-β) as predictive tests for the development and progression of preeclampsia. Seventy five pregnant women (30 mild-PE and 30 sever-PE and 15 normotensive pregnant women) were included in this case-control study. Maternal serum Homocysteine, TNF-α and TGF-β 1 levels were measured in the third trimester by immunosorbent assay (ELISA). Homocysteine and TNF-α serum levels were discriminating between sever and mild-PE which suggests them as PE severity biomarker. Homocysteine, TNF-α and TGF-β increased in the PE group than normotensive pregnant group. The combination between them increased their significance. In conclusion, Women with preeclampsia have high serum homocysteine levels that are directly related to TNF-α and TGF-β and can be considered to play important role in preeclampsia progression.
  Amal Mansour , Hanan Shehata , Marwa Ali , Maha Sallam , Noura El Khouly and Inas Asfour
  Angiogenesis has been shown as an important process in hematological malignancies especially leukemia, Vascular Endothelial Growth Factor (VEGF) plays a central role in promoting angiogenesis. Its different genotypes are associated with many human diseases. This study was to investigate the frequency of -460T/C and -1154G/A VEGF gene SNPs in adult ALL patients and their impact on serum concentration of VEGF and on the clinical outcome. Allele specific PCR for -460T/C and -1154G/A VEGF gene SNPs detection were done for 65 adult subjects (40 ALL patients and 25 normal healthy controls) and the serum VEGF was measured. Mean serum VEGF levels is higher in ALL than control subjects (p = 0.00) and it decreased markedly after complete remission (p = 0.00). There was marked association between TC genotype of -460T/C in ALL with higher association between the C allele and ALL than the T allele (p = 0.018) with high frequency of CA haplotype of -460 T/C and -1154 G/A in patients compared to control group (p = 0.019). Some VEGF genotypes may have impact on ALL pathogenesis and treatment outcome.
  Manar Yehia , Amal Mansour and Sherif Mekawy
  Human Epididymis protein 4 (HE4) has recently been shown to improve the sensitivity and specificity of Epithelial Ovarian Cancer (EOC) diagnosis but its function in cancer cells is not clear. We evaluated HE4 expression, RMI and CA125 serum level as diagnostic tools of primary ovarian cancer in Egyptian women. The HE4 gene expression was evaluated by real time PCR in ovarian cancer of 50 Egyptian women. Ovarian cancer tissues were studied for the detection of the gene expression of HE4 by Quantitative Real Time PCR (Q RT-PCR). Serum Human cancer antigen 125 (CA 125) was measured in the serum of all participants of the study using immune sorbent assay (ELISA). The HE4 showed significant difference among ovarian malignant tumors patients compared to the control subjects (p<0.01). The best cutoff value 0.053 at which HE4 sensitivity was 92% and specificity was 96%. There was a significance correlation between HE4, RMI and CA125 in all patients of the study (p≤0.01 for both). The mRNA expression of HE4 was significantly high versus the control group in early stages and low grades of the disease (p = 0.00, 0.01, respectively). As well as, there was Increased HE4 expression in the late stages of the disease suggesting that it may be associated with poor prognosis as well. The HE4 could be considered as a good prognostic marker for ovarian cancer that increases the sensitivity of the CA 125 to absolute value without affection of CA125 accuracy and its positive predictive value.
 
 
 
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