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Articles by Altan ONAT
Total Records ( 3 ) for Altan ONAT
  Altan Onat , Gunay Can , Hasan Kaya and Gulay Hergenc
 

Objectives

To determine the association of atherogenic index of plasma (AIP), the logarithm of molar ratio of triglyceridemia to high-density lipoprotein cholesterol (TG/HDL-cholesterol) with cardiometabolic disorders was investigated in a sample of the Turkish population.

Methods

A total of 2676 middle-aged adults were prospectively evaluated with a clinical examination and laboratory tests during 7.8 years' follow-up.

Results

AIP was significantly associated in multiple linear regression analyses with greater apolipoprotein B and lower low-density lipoprotein (LDL)-cholesterol levels, reflecting the presence of smaller LDL particle size. Whereas in men insulin levels, obesity, and nonHDL-cholesterol were major determinants, C-reactive protein (CRP) was the strongest determinant of AIP among women, independent of body mass index. Top quartiles of AIP predicted significantly age-adjusted incident coronary heart disease (CHD) in both sexes, more strongly in women, in whom quartile 3 also was a predictor with a greater than 2-fold relative risk. Associations remained significant after adjustment for CRP and traditional risk factors. AIP significantly predicted diabetes and high blood pressure in both sexes after adjustment for age and CRP. With regard to incident high blood pressure, the risk ratio in men was attenuated when body mass index also was adjusted.

Conclusions

High AIP, a surrogate of small LDL particle size, reflects obesity and hyperinsulinemia in men and high CRP status in women. It predicts CHD independently, type 2 diabetes mediated by obesity in men and in women, high blood pressure, metabolic syndrome, and CHD potentially mediated by involvement in a proinflammatory status reflected by CRP.

  GUnay CAN , Peter SCHWANDT , Altan ONAT , Gulay HERGENC and Gerda-Maria HAAS
 

Aim: Determining the difference regarding obesity in German and Turkish adults.

Materials and Methods: This study examined a cross-section of adults aged 30-79 years old. Age-adjustment was uniformly provided for comparisons.

Results: Among 3055 Germans and 2925 Turks, Turkish women had significantly higher markers of (abdominal) obesity than German women, while waist circumference (WC) was similar among males. Blood pressure (BP), concentrations of total, LDL-cholesterol, and apolipoprotein B were significantly higher among Germans, whereas Turks had markedly higher fasting triglycerides and lower HDL-cholesterol. Unlike Germans, the current trend of smoking among Turks correlates with lower WC and lower systolic BP compared to non-smokers. Hip circumference was associated positively with atherogenic dyslipidemia more strongly among Germans than Turks. Changes in circumferences of waist and hip were significantly associated with elevated LDL-cholesterol, independent of BMI, in Germans, but not among Turks. Excess of overall obesity in Germans and Turkish females, and abdominal obesity among Turkish men, in addition to different sex, appeared to be major determinants of SBP. In contrast to Germans and Turkish males, atherogenic dyslipidemia was significantly associated with higher SBP in Turkish females.

Conclusions: Distribution of adiposity, and its interrelationship in German and Turkish adults, reveals substantial disparity that reflects pathogenetic differences; this requires modified emphasis of preventive and therapeutic measures.

  Altan ONAT
  Aim: To assess quantitatively the cumulative and genuine contribution of Turkish universities to science in the main fields over the past 30 years. Materials and methods: In the Citation Reports section of the Web of Science, over 70 main scientific institutions were searched; and publications that received 60 or more citations by May 2010 were selected. Papers having more than a minor share by international authors were excluded. Results: Only 47 universities and 6 institutions generated articles that were cited ≥60 times. These publications, numbering 541, received a total of 51.215 citations. Eight universities (Istanbul University, Istanbul Technical University, Hacettepe University, Bilkent University, Middle-East Technical University, Bogazici University, Ankara University, and Ege University) acquired 62% of these citations. Primary authors were 335 individuals among whom 121 generated 70% of these citations. It is estimated that Turkish scientists produce about 1 per mil of the global scientific output, which indicates that about 40 such papers are produced annually in Turkey. A substantial variance was recorded across major universities in terms of the ratio of citations to highly-cited papers to the total citations. Engineering and geology had higher relative contributions, followed by agricultural sciences, ecology, pharmacy, chemistry and medicine, while physics, mathematics, and biology had less contributions. Conclusion: Along with research in general, research potentially to contribute to science needs specifically to be supported with a coherence, milieu creation and consistent long-term policy.
 
 
 
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