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Articles by Alireza Yousefi
Total Records ( 2 ) for Alireza Yousefi
  Ali Aliabadi , Alireza Yousefi , Amirashkan Mahjoor and Maryam Farahmand
  Milk thistle is native to the Mediterranean region. The plant’s leaves and seeds have been used continuously since, at least Greco-Roman days for treating many ailments particularly those that affect the liver. Silymarin and silybin used so far mostly as hepatoprotectants were shown to have other interesting activities. These activities were demonstrated in a large variety of illnesses of different organs as e.g., prostate, lungs, CNS, kidneys, pancreas and others. Besides the cytoprotective activity of silybin mediated by its antioxidative and radical-scavenging properties also new activities based on the specific receptor interaction were discovered e.g., inhibition and modulation of drug transporters, P-glycoproteins, estrogenic receptors, nuclear receptors and some others. The objective of the study is to evaluate the diabetic wound healing activity of Silybum marianum using the excision wound model in a streptozotocin induced diabetic rats. The animals were weight matched and placed into seven groups (n = 10 group). Group I, normal control rats. Group II, normal scheme rats which were treated with simple ointment base. Groups III and IV, diabetic control and scheme. Groups V-VII, diabetic test rats which were treated with 5, 10 and 20% silymarin ointment. All animals were experimentally wounded on the posterior surface. The efficacy of treatment was evaluated based on wound area relative and histopathological characteristics. The silymarin ointment treated diabetic animals showed significant reduction in the wound area when compared with diabetic control and all other groups. Also, histological studies of the tissue obtained on day 7th and 15th from the treatment groups by silymarin ointment showed increased well organized bands of collagen, more fibroblasts and few inflammatory cells. There was no significant (p<0.05) difference between treatment groups. These findings demonstrate that 5, 10 and 20% ointment of silymarin effectively stimulates wound contraction as compared to control group and other groups and may be useful in treatment of diabetic wounds.
  Abdolreza Sotoodeh Jahromi , Karamatollah Rahmanian , Mohammad Hasan Davami , Hassan Zabetian , Alireza Yousefi and Abdolhossien Madani
  Patients with beta-thalassaemia major and asplenia have an increased risk of encapsulated bacterial infections. The aim of this study was to determine the Haemophilus influenza type b (Hib) antibody concentrations in beta-thalassaemia patients with or without spleens. The Hib antibody concentrations were investigated in 850 patients with thalassaemia major, of whom 437 had undergone splenectomy. Hib antibody levels equal or greater than 1.0 μg mL-1 were classified as long-term protection, those between 0.15 and less than 1.0 μg mL-1 as short term protection and those less than 0.15 μg mL-1 as no protection. The mean Hib antibody level was lower in asplenic subjects than in non splenectomised subjects (0.39±0.5 vs. 1.08±0.55 μg mL-1, p<0.001). The protective antibody level prevalence in asplenic patients was significantly lower than that in patients with spleens (32.3% vs. 85.7%, p<0.001). Protection against Hib decreased as the time interval after splenectomy increased from 57.2% at a less than 60 months interval to 10.8% at a greater than 120 months interval (p = 0.001). Nearly 30% of the 437 splenectomised subjects had long-term protection against Hib, whereas 64.4% of the 413 non splenectomised subjects had long term protection (p<0.001). Asplenic subjects had lower Hib antibody levels than non splenectomised subjects. Additionally, the antibody levels decreased as the time interval increased after splenectomy. A Hib vaccine recommendation for splenectomised thalassaemia major seems essential.
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