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Articles by Alireza Garjani
Total Records ( 3 ) for Alireza Garjani
  Sadollah Mohammadi , Alireza Garjani , Moslem Najafi , Hossein Hamzeiy , Nasrin Maleki-Dizaji , Yadollah Omidi , Shabnam Fayezi , Masoud Darabi , Sara Mostafalou , Kambiz Hassanzadeh and Sajjad Khani
  Methylsulfonylmethane (MSM) is naturally accruing organic sulphur that is known as a potent anti-inflammatory compound. The aim of this study was to investigate the effect of MSM on mRNA expressions of angiotensinogen, endothelin-1 (ET-1) and Transforming Growth Factor (TGF)-β1 in rats with monocrotaline (MCT)-induced pulmonary arterial hypertension. Wistar rats were randomly assigned to 38-days pretreatment or 28-days treatment. MSM was administered to either 10 days before or 14 days after a single dose of MCT. Right Ventricle (RV) tissue samples were obtained to evaluate changes in the inflammatory genes expression using RT-PCR assay. The expression levels of angiotensinogen, ET-1 and TGF-β1 significantly were reduced (p<0.01) at efficient dose of MSM in MCT-induced pulmonary arterial hypertensive rats. Results suggest that harmful effects of MCT induced PAH on the RV function could be attenuated by anti-inflammatory actions through the suppression of local RAAS along with associated growth-promoting factors TGF-β1 and ET-1.
  Yousef Doustar , Daryoush Mohajeri , Alireza Garjani , Ghafour Mousavi and Mehrdad Neshat Ghramaleki
  The heart failures following infarctions is one of the most important causes of death throughout the world. This study was undertaken to investigate the protective effects of metformin on apoptotic cell death of cardiomyocytes during experimental cardiac Ischemia-Reperfusion (IR) in rats. The 25 male Wistar rats were randomly assigned into 5 groups of 5 animals each including; Sham/IR, IR, low dose metformin+IR, average dose metformin+IR and high dose metformin+IR. Heart muscle ischemia was induced clamping the left descending coronary artery. After 30 min of ischemia, the clamps were taken off and the animals underwent 2 h reperfusion. Metformin (5, 10 and 20 μg/kg/min) was infused 15 min prior to reperfusion through jugular vein in treatment groups. At the end of experiment, the rats were euthanized and histological sections from left ventricles were prepared through Tunnel Staining method. Apoptotic cells were counted under light microscope. The data obtained were statistically analyzed using ANOVA. Differences were considered statistically significant at p<0.05. In group 2, ischemia-reperfusion caused occurrence of apoptotic cell death in cardiomyocytes. There was a significant increase in the incidence rate of apoptosis of cardiomyocytes in comparison with group 1 (p<0.001). In groups 3-5 metformin (5, 10 and 20 μg/kg/min) caused significant decrease in the number of apoptotic cells in comparison with group 2 (p<0.05, p<0.01 and p<0.001, respectively). This study therefore, suggests that metformin may be a useful agent for the prevention of Ischemia-Reperfusion (IR) induced apoptotic cell death of cardiomyocytes in a dose dependent manner in the rats.
  Yousef Doustar and Alireza Garjani
  Colorectal cancer is a major health problem worldwide. Resveratrol is a stilbenoid, a type of natural phenol and a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. The main objective of present study was to immunohistochemical assessment of the effect of resveratrol on the expression of β-catenin protein in experimental colonic carcinoma of rat. The 25 male Wistar rats aged 3-4 months old weighting 250-350 g were selected by chance. The rats of group 1 were received standard food and water without any changes in their nutritional condition. Rats of group 2 were received EDTA at the dose of 40 mg kg-1 as promotor of DMH twice a week for 2 weeks. Rats of group 3 were received DMH at the dose of 40 mg kg-1 twice a week for 2 weeks for induction the cancer. The rats of groups 4 and 5 after induction of cancer were received resveratrol at the dose of 10 and 20 mg/kg/day for 10 weeks orally, respectively. The 12 weeks after treatment with resveratrol, animals were constrained and anesthetized by xylazine and ketamine intraperitoneally. Then, segments of colon were sampled for histopathological assessments. Immunohistochemical evaluations showed that rate of the expression of β-catenin proteins in treatment groups was less than control group and there is a statistical significance among groups (p<0.01).
 
 
 
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