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Articles by Ali UZUNKOY
Total Records ( 2 ) for Ali UZUNKOY
  Abdullah OZGONUL , Nurten AKSOY , Fuat DILMEC , Ali UZUNKOY and Şahin AKSOY
 

Aim: The aim of this study was to compare the antioxidative status in patients with colorectal cancer and healthy controls, based on measurements made using a novel method.

Materials and Methods: The study was conducted between 2005 and 2007, and included 30 patients with colorectal cancer and 30 healthy controls. To determine the antioxidative status of the patients and healthy controls, serum total antioxidant capacity was measured using a novel automated method. Blood samples were taken from the healthy controls and the patients.

Results: Total serum antioxidant capacity was significantly lower in colorectal cancer patients than in healthy persons (P < 0.023).

Conclusions: Patients with colorectal cancer are exposed to oxidative stress, which may have a role in the pathogenesis of the disease. The novel automated method used in this study was developed in our laboratory, and is feasible and fully automated; therefore, it may be useful for evaluating oxidative-antioxidative balance in patients with colorectal cancer.

  Mustafa ZERIN , Ali Ziya KARAKILCIK , Muharrem BITIREN , Davut MUSA , Abdullah OZGONUL , Sehabettin SELEK , Yasar NAZLIGUL and Ali UZUNKOY
  Aim: Free radicals are an important factor in the etiopathogenesis of colitis and may increase oxidative damage. The antioxidant vitamin C efficiently scavenges free oxygen radicals. The present study aimed to investigate the probable protective effects of vitamin C on oxidative injury in rats in which colitis was experimentally induced with acetic acid. Materials and methods: This study was conducted with rats for a period of 7 days. Group 1 intrarectally received a placebo (0.9% NaCl) and group 2 intrarectally received 2 mL of 5% acetic acid (AA) and the placebo. Group 3 intrarectally received 2 mL of 5% AA and vitamin C (100 mg/kg of body weight) via gastric gavage. Myeloperoxidase (MPO), catalase (CAT), prolidase (PRS), and arylesterase (ARE) activity, and total thiol (T-SH), total antioxidant capacity (TAC), total oxidant status (TOS), lipid hydroperoxide (LOOH), and oxidative stress index (OSI) values were analyzed in blood and intestinal samples. Results: While CAT and PRS activity, and plasma TOS, LOOH, and OSI increased following the administration of AA, TAC decreased. TAC increased, whereas LOOH and OSI decreased in response to vitamin C treatment. While MPO and CAT activity, and TOS, LOOH, and OSI values in the colon increased in response to AA treatment, PRS, ARE, T-SH, and TAC decreased. TAC increased in response to vitamin C, whereas MPO, PRS and ARE activity, and TOS, LOOH, and OSI values decreased. While histopathologic colonic injury scores increased (P < 0.001) in response to AA, they decreased in response to vitamin C. Conclusion: Histopathological damage scores, MPO, TOS, LOOH, and OSI decreased significantly in response to vitamin C treatment, whereas TAC increased. Based on these results, we think that vitamin C might play an important role in preventing oxidative stress and colonic tissue injury produced by acetic acid.
 
 
 
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